QK1 (QKI) (pan) Mouse Monoclonal Antibody [Clone ID: S147-6]

SKU AM60063PU-N

QK1 (QKI) (pan) mouse monoclonal antibody, clone S147-6, Purified

Product Data

• Clone Name: S147-6
• Application: IF, IHC, WB
• Recommended Dilution: Western blot: 1/1000; 1 μg/ml was sufficient for detection of QKI (pan) in 20 μg of rat brain lysate by colorimetric immunoblot analysis using HRP conjugated secondary antibody.; Immunocytochemistry.; Immunohistochemistry: Free floating sections, fixed in formaldehyde.
• Reactivity: Human, Mouse, Rat
• Antibody Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 1-341 (full-length) of human QKI-5 (accession number Q96PU8, isoform 1) with >90% identity with QKI-6, QKI-7 and QKI-7b.
• Specificity: This antibody detects a 36-38 kDa protein corresponding to the molecular weight of QKI (pan).
• Buffer: PBS pH 7.4, 50% Glycerol, 0.09% Sodium azide; State: Purified; State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Protein G chromatography
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C. ; Avoid repeated freezing and thawing.
• Stability: Shelf life: One year from despatch.
• Shipping: Blue Ice
• Gene Name: QKI, KH domain containing, RNA binding
• Database Link:
  Q96PU8
• Background: QKI is also called Protein Quaking or HqkI. QKI is an RNA-binding protein that plays a central role in myelinization. QKI acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, and is itself, regulated by alternative splicing. QKI is expressed in the frontal cortex of brain, but is shown to be down-regulated in the brain of schizophrenic patients. Several isoforms are known.
• Synonyms: HKQ, QK1, QK3

Reference Data