Thymine DNA glycosylase (TDG) Mouse Monoclonal Antibody [Clone ID: AT2F7]

CAT#: AM50036PU-N

Thymine DNA glycosylase (TDG) mouse monoclonal antibody, clone AT2F7, Purified

Size: 50 ul 100 ul


USD 426.00

3 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Clone Name AT2F7
Applications ELISA, WB
Recommended Dilution The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:250.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant human TDG (1-410aa) purified from E. coli
Formulation PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
State: Purified
State: Liquid purified IgG fraction
Concentration lot specific
Purification Protein-A affinity chromatography
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene. Several bacterial proteins have strong sequence homology with this protein. The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
Synonyms E130317C12Rik; hTDG; JZA-3; Jza1; OTTMUSP00000028912; OTTMUSP00000028913
Reference Data
Protein Families Druggable Genome
Protein Pathways Base excision repair

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.