ACOX1 Mouse Monoclonal Antibody [Clone ID: 153CT43.1.1]
| Product Data | |
| Clone Name | 153CT43.1.1 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | Western blot: 1/100-1/500. Immunofluorescence: 1/10-1/50. Immunohistochemistry on Paraffin Sections: 1/10-1/50. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | ACOX1 recombinant protein. |
| Specificity | This antibody recognizes Human ACOX1. Other species not tested. |
| Buffer | PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% (W/V) Sodium Azide |
| Concentration | lot specific |
| Purification | Protein G Chromatography, followed by dialysis against PBS |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | acyl-CoA oxidase 1, palmitoyl |
| Database Link | |
| Background | ACOX1 is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Function: Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA. Cellular Location: Peroxisome. Tissue Location: Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart. |
| Synonyms | AOX, Palmitoyl-CoA oxidase, Straight-chain acyl-CoA oxidase |
| Reference Data | |
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