ICAM3 Mouse Monoclonal Antibody [Clone ID: JA4]

SKU AM33037PU-N

ICAM3 mouse monoclonal antibody, clone JA4, Purified

Product Data

• Clone Name: JA4
• Application: ELISA, FC, IF, IHC, IP, WB
• Recommended Dilution: ELISA. ; Western Blot.; Immunoprecipitation.; Flow Cytometry. ; Immunocytochemistry.; Immunohistochemistry on Frozen Sections. ; Recommended Dilutions: 1/100–1/200 for Flow Cytometry, and for Immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1/100–1/1000 for Immunoblotting applications.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Derived by fusion of mouse Ag8.653 cells with spleen cells from a BALB/c mouse immunized with an ICAM-3/HEK transfectant.
• Specificity: This JA4 antibody recognizes a linear epitope in domains 1 and 2 of ICAM-3.
• Buffer: PBS; State: Purified; State: Liquid purified IgG fraction; Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: intercellular adhesion molecule 3
• Database Link:
  P32942
• Background: Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a type I transmembrane glycoprotein, which normally contain 2-9 immunoglobulin-like C2-type domains, and binds to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. ICAM-3 has previously been implicated in apoptotic cell clearance, although its precise role in the clearance process is ill defined.
• Synonyms: ICAM-3, ICAM-R, CDw50

Reference Data