EMA (MUC1) Mouse Monoclonal Antibody [Clone ID: 139H2]
Product Data | |
Clone Name | 139H2 |
---|---|
Application | ELISA, EM, FC, IF, IHC, IP, WB |
Recommended Dilution | ELISA. Western blot. Electron Microscopy. Flow Cytometry. Immunofluorescence. Immunoprecipitation. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections: 10 µg/ml. |
Reactivity | Human |
Antibody Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human milk-fat globule membranes (HMFGM). |
Specificity | This Mouse monoclonal antibody has been raised against Human milk-fat globule membranes (HMFGM) to obtain reagents for mammary tumor diagnosis. This monoclonal reacts towards an peptide epitope in the repeat region of MUC-1. |
Buffer | PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Stability | Shelf life: one year from despatch. |
Shipping | Blue Ice |
Gene Name | mucin 1, cell surface associated |
Database Link | |
Background | Mucin 1, cell surface associated (MUC-1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. MUC-1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with colon, breast, ovarian, lung and pancreatic cancers. |
Synonyms | MUC-1, PEMT, Episialin, EMA, H23AG, PUM, DF3, CA 15-3 |
Reference Data |
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