PRUNE (PRUNE1) Mouse Monoclonal Antibody [Clone ID: 1C11]

CAT#: AM31933PU-N

PRUNE (PRUNE1) mouse monoclonal antibody, clone 1C11, Purified

Product Images

Western Blot analysis of PRUNE expression in transfected 293T cell line by PRUNE monoclonal antibody, clone 1C11.

• 

  Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 1C11
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant protein
• Specificity: This antibody recognizes Human PRUNE.
• Formulation: PBS, pH 7.2
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: prune exopolyphosphatase
• Database Link:
  Entrez Gene 58497 Human
  UniProt ID Q86TP1
• Background: PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumours of mesenchymal origin. Human prune (h-prune), a phosphoesterase DHH family appertaining protein, physically interacts with nm23-H1, a metastasis suppressor gene. h-prune is involved in cellular motility and metastasis formation. Metastatic breast cancers were found to overexpress h-prune; h-prune was also found to be highly expressed in colorectal and pancreatic cancers. Hence h-prune is considered useful as a marker for tumor aggressiveness.
• Synonyms: Protein prune homolog, hPrune, HTcD37, DRES17, DRES-17

Reference Data

• Protein Pathways: Purine metabolism