BCL3 Hamster Monoclonal Antibody [Clone ID: Ham150-3.5]

CAT#: AM31856PU-N

BCL3 hamster monoclonal antibody, clone Ham150-3.5, Purified

Product Images

Western Blot Analysis of bcl-3 antibody: Lysate from Mouse Spleen and Thymus (Thymus shown above) cells probed with at 1.0 ug/ml. AP conjugated Goat Anti-Hamster IgG as secondary antibody.

Specifications

Product Data

• Clone Name: Ham150-3.5
• Applications: ELISA, FC, WB
• Recommended Dilution: This Clone has been described to work in ELISA, Western Blot and Flow Cytometry.
• Reactivities: Human, Mouse
• Host: Hamster
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Bcl-3-6-histidine tag from Armenian Hamster.
  Fusion Partner: SP2/0 myeloma.
• Specificity: Recognizes B-cell Leukemia/lymphoma 3 (Bcl-3).
• Formulation: PBS containing 0.02% Sodium Azide as preservative
  State: Purified
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Protein G Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: B-cell CLL/lymphoma 3
• Database Link:
  Entrez Gene 602 Human
  UniProt ID P20749
• Background: B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells.
  Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin. The Mouse Bcl-3 coding region exhibits 80% homology with Human Bcl-3 which is associated with human B-cell chronic lymphocytic leukemias (CLLs).
  Bcl-3 is detected in various tissues such as spleen and other lymphoid organs.
• Synonyms: BCL3, BCL4, D19S37

Reference Data

• Protein Families: Druggable Genome, Transcription Factors