PMP22 (N-term) Mouse Monoclonal Antibody [Clone ID: CF1]

SKU AM26200PU-N

PMP22 (N-term) mouse monoclonal antibody, clone CF1, Purified

Product Data

• Clone Name: CF1
• Application: ELISA, IHC, WB
• Recommended Dilution: Immunoassay.; Western blot: The typical starting working dilution is 1:50.; Immunohistochemistry on paraffin sections.
• Reactivity: Human, Monkey, Rhesus Monkey
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Peptide corresponding to amino acids 121-133 in the second extracellular domain of human PMP2 with an extra N-terminal cysteine residue
• Specificity: This antibody recognizes human peripheral myelin protein 22 (PMP22).
• Buffer: PBS; State: Purified; State: Liquid 0.2 µm filtered Ig fraction; Stabilizer: 0.1% bovine serum albumin; Preservative: 0.02% sodium azide
• Concentration: lot specific
• Purification: Protein G
• Conjugation: Unconjugated
• Storage:

  Store at 2 - 8 °C.;

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Gene Name: peripheral myelin protein 22
• Database Link:
  Q01453
• Background: PMP22 is a 160 amino acid glycoprotein and contains four hydrophobic domains, presumably transmembrane regions. It is the second most abundant protein in the mammalian nervous system, but is, at least in rodents, also found in other tissues, including the liver and gut. Myelin protein zero (P0) is the most abundant protein in mammalian peripheral nerve myelin. An interaction between P0 and PMP22 has been detected in compact myelin. Defects in PMP22 have been related to Charcot-Marie-Tooth disease (CMT) and inflammatory demyelinating neuropathy (IDP). Immunization with PMP22 induces experimental auto-immune neuritis without central nervous inflammation. Therefore, PMP22 is considered as candidate auto-antigen in inflammatory diseases of the peripheral nervous system, including both acute and chronic inflammatory demyelinating polyradiculoneuropathy.
• Synonyms: PMP-22, GAS3, GAS-3, Peripheral myelin protein 22

Reference Data