TAPA1 (CD81) Mouse Monoclonal Antibody [Clone ID: M38]

SKU AM26031PU-N

TAPA1 (CD81) mouse monoclonal antibody, clone M38, Purified

Product Data

• Clone Name: M38
• Application: FC, FN, IF, IHC, IP, WB
• Recommended Dilution: Flow cytometry: 1 µg/ml.; Immunoprecipitation.; Western blot.; Immunohistochemistry on paraffin sections.; Immunocytochemistry.; Functional Application: In human MOLT-4 T-cell line the antibody M38 inhibits syncytium formation induced by coculture with human T-cell leukemia virus type 1 (HTLV-1)-positive human T-cell lines.
• Reactivity: Feline, Human, Rabbit
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: MOLT-4 (human T-ALL cell line)
• Specificity: This antibody reacts with CD81, a 25 kDa member of the tetraspanin family, expressed on majority of cells.
• Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4; State: Purified; State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Protein-A affinity chromatography (> 95% by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.; DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: CD81 molecule
• Database Link:
  P60033
• Background: CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells – e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.
• Synonyms: S5.7; TAPA-1; TAPA1; Tetraspanin-28; Tspan-28; TSPAN28

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: B cell receptor signaling pathway