MCK10 (DDR1) Mouse Monoclonal Antibody [Clone ID: 2G4E12]

SKU AM20432SU-N

MCK10 (DDR1) mouse monoclonal antibody, clone 2G4E12, Ascites

Product Data

• Clone Name: 2G4E12
• Application: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/10000.; Immunohistochemistry on Paraffin Sections: 1/200 - 1/300.; Western Blot: 1/500 - 1/2000.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified Recombinant fragment of DDR1 (aa 602-681) expressed in E.coli
• Specificity: Recognizes Human Discoidin Domain Receptor (DDR1).
• Buffer: State: Ascites; State: Ascites fluid; Preservative: 0.03% Sodium Azide
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. ; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: discoidin domain receptor tyrosine kinase 1
• Database Link:
  Q08345
• Background: DDR1 is a DDR/TKT type protein kinase. DDR1 is activated by various types of collagen, including types I through IV. Binding of collagen to DDR1 protein results in autophosphorylation and a delayed but sustained tyrosine kinase activation. DDR1 may function in cell-to-cell interaction or recognition. At least three mRNA variants, resulting in different protein isoforms of 875, 913 and 919 amino acids, have been reported. DDR1 protein has been shown to be over expressed in human breast, ovarian, esophageal and pediatric brain tumors.
• Synonyms: Tyrosine kinase DDR-1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE, MCK10, Epithelial discoidin domain receptor 1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane