p27 KIP 1 (CDKN1B) Mouse Monoclonal Antibody [Clone ID: SX53G8]
| Product Data | |
| Clone Name | SX53G8 |
|---|---|
| Application | IHC |
| Recommended Dilution | Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/50-1/200 Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended. Use Polymer anti Mouse/Rabbit IgG as a detection system. Positive Control: Colon carcinoma. |
| Reactivity | Canine, Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Purified glutathione S-transferase (GST)-p27Kip1 fusion protein. |
| Specificity | Recognizes p27Kip1. Clone SX53G8 co-precipitates cdk4 in complex with p27Kip1 and is excellent for staining of formalin fixed tissues. Cellular Localization: Nuclear. |
| Buffer | State: Supernatant State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide. |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | cyclin-dependent kinase inhibitor 1B |
| Database Link | |
| Background | p27Kip1, a candidate tumor suppressor gene, functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF-beta induced G1 arrest. |
| Synonyms | p27Kip1 |
| Reference Data | |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS |
| Protein Pathways | Amyotrophic lateral sclerosis (ALS) |
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