H2-D1 Mouse Monoclonal Antibody [Clone ID: 28-14-8]

CAT#: AM08080FC-N

H2-D1 mouse monoclonal antibody, clone 28-14-8, FITC

Conjugation: Unconjugated Biotin FITC PE



USD 476.00

3 Days*

Size
    • 500 ug

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Specifications

Product Data
Clone Name 28-14-8
Applications FC
Recommended Dilution Flow Cytometry: ≤ 1 µg/106 cells.
Reactivities Mouse
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen C3H.SW mouse splenocytes. (Ref.1,2)
Specificity This antibody is specific to an epitope in the alpha 3 domain of H-2Db. It binds to the alpha 3 domain of H-2Db in the presence or absence of beta 2 microglobulin. (Ref.7,8) It cross reacts with the alpha 3 domain of H-2Ld, but not Kd or Dd, and with H-2Dq and/or Lq.
The antibody has been shown to block H-2Ld-specific and H-2Ld-restricted antigen-specific lysis of target cells by cytotoxic T lymphocytes, (Ref.9-11) but it does not block recognition of H-2Ld-positive target cells by Ly-6G2-positive NK cells. (Ref.12).
Customer feedback: Clone 28-14-8 does not cross-react with Human cells.
Formulation 1.0 ml PBS containing 0.09% Sodium Azide as preservative
Label: FITC
State: Liquid purified IgG fraction
Label: Fluorescein Isothiocyanate Isomer 1
Concentration lot specific
Conjugation FITC
Storage Store undiluted at 2-8°C.
This product is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Background The 'classical' MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant beta 2-Microglobulin. (Ref.3,4) These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. (Ref.5)
Synonyms H-2D(B), H2-D1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.