PKN2 Mouse Monoclonal Antibody [Clone ID: 1D1]
Specifications
| Product Data | |
| Clone Name | 1D1 |
|---|---|
| Application | ELISA, FC, IHC, WB |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry on paraffin sections: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. |
| Reactivity | Human, Monkey, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Purified recombinant fragment of human PRK2 expressed in E. Coli. |
| Specificity | This antibody reacts to PRK2. |
| Buffer | State: Ascites State: Ascitic fluid containing 0.03% sodium azide. |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 140 kDa |
| Gene Name | protein kinase N2 |
| Database Link | |
| Background | Protein-kinase-C-related kinases (PRKs) are part of the lipid-regulated protein kinases (PKC) which also include liver PAK & PKN. Human PRK1 and PRK2 share structurally similar catalytic domains, but less similar N-terminal regulatory regions suggesting different regulatory domain functions. PRK1 and PRK2, as well as a third member of this family, PRK3, show distinct patterns of expression in adult tissues. Additionally, the serine-threonine kinase PRK2 can be specifically cleaved by caspase-3 (and/or caspase-3-like subfamily members) during apoptosis. |
| Synonyms | PRK2, PRKCL2, Protein kinase C-like 2 |
| Reference Data | |
| Protein Categories | Cytokines, Enzyme: Kinases, Intracellular Proteins, Membrane Proteins |
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