CD38 Mouse Monoclonal Antibody [Clone ID: 6E12D]

SKU AM06390SU-N

CD38 mouse monoclonal antibody, clone 6E12D, Ascites

Product Data

• Clone Name: 6E12D
• Application: ELISA, IHC, WB
• Recommended Dilution: Western Blot: 1/500 - 1/2000.; Immunohistochemistry on paraffin sections: 1/200 - 1/1000.; ELISA: 1/10000.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of human CD38 expressed in E. Coli.
• Specificity: This antibody reacts to CD38.
• Buffer: State: Ascites; State: Ascitic fluid containing 0.03% sodium azide.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Predicted Protein Size: 34 kDa
• Gene Name: CD38 molecule
• Database Link:
  P28907
• Background: CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lym- phocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabo- lites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.
• Synonyms: cADPr hydrolase 1, T10

Reference Data