ATP2C1 Mouse Monoclonal Antibody [Clone ID: 4G12]

SKU AM06380SU-N

ATP2C1 mouse monoclonal antibody, clone 4G12, Ascites

Product Data

• Clone Name: 4G12
• Application: ELISA, IHC, WB
• Recommended Dilution: Western Blot: 1/500 - 1/2000.; Immunohistochemistry on paraffin sections: 1/200 - 1/1000.; ELISA: 1/10000.
• Reactivity: Human, Monkey
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of ATP2C1 expressed in E. Coli.
• Specificity: This antibody reacts to ATP2C1.
• Buffer: State: Ascites; State: Ascitic fluid containing 0.03% sodium azide.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Predicted Protein Size: 100 kDa
• Gene Name: ATPase secretory pathway Ca2+ transporting 1
• Database Link:
  P98194
• Background: ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (alsodesignated SPLA in rat), also regulates the transport of calcium in the Golgicomplex and is related to other P-type ATPases family members, such as thesarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calciumATPase (PCMA). ATP2C1 is a transmembrane protein that exists as twosplice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
• Synonyms: ATPase 2C1, KIAA1347, PMR1L, HUSSY-28, ATP-dependent Calcium pump PMR1

Reference Data