FER Mouse Monoclonal Antibody [Clone ID: 5D2C4]

SKU AM06187SU-N

FER mouse monoclonal antibody, clone 5D2C4, Ascites

Product Data

• Clone Name: 5D2C4
• Application: IF, IHC, WB
• Recommended Dilution: ELISA: 1/10000.; Western Bloting: 1/500 - 1/2000.; Immunofluorescence: 1/200 - 1/1000. ; Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
• Reactivity: Human, Mouse
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of human FER expressed in E. Coli.
• Specificity: Recognizes FER (fer tyrosine kinase).
• Buffer: State: Ascites; State: Ascitic fluid containing 0.03% Sodium Azide.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Predicted Protein Size: 95 kDa
• Gene Name: FER tyrosine kinase
• Database Link:
  P16591
• Background: FER (fer tyrosine kinase) is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases, which shares a functional domain and is involved in signaling pathways through receptor tyrosine kinases (RTK) and cytokine receptors. The Fes /Fps family is distinct from c-Src, c-Abl and related nRTKs and was originally distinguished as a homolog to retroviral oncoproteins. In vivo, Fer kinase assembles into homotrimers via conserved coiled-coil domains. The N-terminal coiled-coil domains of Fer can autophosphorylate in trans, thereby regulating their cellular function through differential phosphorylation states. Growth factor exposure can induce tyrosine phosphorylation of Fer and recruitment of Fer to RTK complexes containing p85. It is expressed predominantly in mature hematopoietic cells of the granulocytic and monocytic lineage, and has been shown to be expressed in vascular endothelial cells. Fer is implicated in insulin signaling, cell-cell signaling, human prostatic proliferative diseases, and is involved in the regulation of G1 progression.
• Synonyms: c-FER, p94-FER, Tyrosine kinase 3

Reference Data