CD272 (BTLA) Mouse Monoclonal Antibody [Clone ID: MIH26]
CD272 (BTLA) mouse monoclonal antibody, clone MIH26, Purified
Product Datasheet for 'AM05617PU-N'
|Recommend Dilution||Flow Cytometry: Use 10 µl of 1/10-1/200 diluted antibody to label 1x106 cells in 100 µl.
Immunohistochemistry on Frozen Sections.
Histology Positive Control Tissue: Human tonsil.
|Immunogen||BTLA - transfected L cells|
|Specificity||This antibody detects CD272, also known as B- and T-lymphocyte attenuator (BTLA).|
|Formulation||PBS, pH 7.4
State: Liquid purified IgG fraction
Preservative: 0.09% Sodium Azide
|Purification||Affinity Chromatography on Protein G|
|Background||CD272 is a type I transmembrane glycoprotein which is structurally and functionally related to cytotoxic T lymphocyte antigen-4 (CTLA-4), and programmed death-1 (PD-1). CD272 is a T-cell inhibitory receptor that regulates T cell activation through its interaction with herpes virus entry mediator (HVEM), a co-stimulator receptor of the TNFR family.
CD272 may negatively regulate T-cell dependent autoimmune reaction, and polymorphisms in its gene have been associated with Rheumatoid Arthritis.
|Synonyms||BTLA1; CD272; FLJ16065; MGC129743|
|AM05617PU-L||Mouse Monoclonal Anti-BTLA Antibody, Purified||