CD24 Mouse Monoclonal Antibody [Clone ID: SN3]

CAT#: AM03032LE-N

CD24 mouse monoclonal antibody, clone SN3, Low Endotoxin

Specifications

Product Data

• Clone Name: SN3
• Applications: FC, IHC
• Recommended Dilution: Immunohistochemistry on frozen sections.
  Flow Cytometry.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Glycoproteins purified from human NALM-1 cell line
• Specificity: This antibody recognises the CD24 cell surface antigen, a heavily glycosylated molecule of 35-45kD, expressed by granulocytes and B lymphocytes, and by some activated T cells and T cell malignancies.
• Formulation: Phosphate buffered saline pH7.4
  State: Low Endotoxin
  State: Liquid purified IgG
• Concentration: lot specific
• Purification: Affinity chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Store the antibody at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: CD24 molecule
• Database Link:
  Entrez Gene 100133941 Human
  UniProt ID P25063
• Background: CD24 (also known as heat stable antigen) is a phosphatidylinositol linked cell surface glycoprotein with a polypeptide core of 30 amino acids and high carbohydrate content. The apparent molecular mass of the two forms of CD24 purified from a mouse lymphoma cell line appear to be in the range of 40-60 and 23-30 kDa. CD24 is expressed at all stages of B cell development and on most thymocytes. The absence of expression from mature T cells is closely associated with their maturation from CD4+ CD8+ CD24+ thymocytes to either CD4+ CD8- CD24- or CD4- CD8+ CD24- T cells. CD24 is also present on mouse granulocytes, monocytes, Langerhans cells and erythrocytes. Its ligand is P selectin (CD62P). CD24 may play a role in regulation of B cell proliferation and differentiation, and it has been proposed that heat stable antigen promotes homotypic adhesion between B lymphocytes. CD24 is also a positive marker of pancreatic cancer.
• Synonyms: X62 heat stable antigen, HSA
• Note: Endotoxin Level: <0.01EU/µg