Complement C4d (C4d) (neoepitope) Mouse Monoclonal Antibody [Clone ID: 057-51.5.1.6]

SKU AM01350PU-N

Complement C4d (C4d) (neoepitope) mouse monoclonal antibody, clone 057-51.5.1.6, Purified

Product Data

• Clone Name: 057-51.5.1.6
• Application: ELISA, FC, IHC
• Recommended Dilution: ELISA.; Flow Cytometry.; Immunohistochemistry on Frozen Sections.; Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified Human C4d.
• Specificity: This antibody recognizes a neoantigen on the secreted protein complement component 4d (C4d).
• Buffer: Borate buffered saline; State: Purified; State: Liquid purified IgG fraction; Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Background: The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4bs alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation. C4 has been linked to susceptibility to systemic lupus erythematosous.
• Synonyms: Complement component 4, CPAMD2, CPAMD3, Acidic complement C4, Basic complement C4

Reference Data