MAPT / TAU (Isoform 13) Mouse Monoclonal Antibody [Clone ID: C45]

CAT#: AM00187PU-N

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MAPT / TAU (Isoform 13) mouse monoclonal antibody, clone C45, Aff - Purified



USD 440.00


Availability*
3 Weeks

Size
    • 100 ul


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Specifications

Product Data
Clone Name C45
Applications IHC, IP, WB
Recommended Dilution Western Blot: 1/1000.
Immunoprecipitation: 1/500.
Immunohistochemistry: 1/100.
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Synthetic peptide corresponding to the N-terminus of of the longest isoform of Human Tau.
Specificity The antibody recognizes 45-60 kDa Tau-13.
Formulation PBS containing 50% Glycerol, 1% BSA and 0.02% Sodium Azide
State: Aff - Purified
State: Liquid ascites
Conjugation Unconjugated
Storage Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimers disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimers disease.
Synonyms MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein, Paired helical filament-tau
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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