MAPT / TAU (Isoform 13) Mouse Monoclonal Antibody [Clone ID: C45]
MAPT / TAU (Isoform 13) mouse monoclonal antibody, clone C45, Aff - Purified
|Applications||IHC, IP, WB|
|Recommended Dilution||Western Blot: 1/1000.
|Immunogen||Synthetic peptide corresponding to the N-terminus of of the longest isoform of Human Tau.|
|Specificity||The antibody recognizes 45-60 kDa Tau-13.|
|Formulation||PBS containing 50% Glycerol, 1% BSA and 0.02% Sodium Azide
State: Aff - Purified
State: Liquid ascites
|Storage||Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Background||Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimers disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimers disease.|
|Synonyms||MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein, Paired helical filament-tau|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.