TGF beta 2 (TGFB2) (NM_001135599) Human Recombinant Protein

CAT#: TP723805

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Purified recombinant protein of Human transforming growth factor, beta 2 (TGFB2), transcript variant 1


 Product Datasheet for 'TP723805'

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USD 250.00


Availability*
5 Days

Size
    • 5 ug


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Specifications

Product Data
Description Purified recombinant protein of Human transforming growth factor, beta 2 (TGFB2), transcript variant 1
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence Human TGF-beta;2, the region of Ala303-Ser414, from gene Accession# NM_001135599.2
Tag Tag Free
Predicted MW 12.7 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >98%, as determined by Coomassie stained SDS-PAGE.
Buffer 20% Acetonitrile, 0.1% TFA (Trifluoroacetic acid)
Bioactivity The ED50 is 1 - 4 ng/ml, corresponding to a specific activity of 0.25 - 1.0 x 10^6 units/mg.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method.
Reference Data
RefSeq NP_001129071
Locus ID 7042
Cytogenetics 1q41
Refseq ORF 1326
Synonyms G-TSF; LDS4; TGF-beta2
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway

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