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ErbB 3 (ERBB3) (NM_001982) Human Recombinant Protein

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SKU
TP700010
Recombinant extracellular domain of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant 1, expressed in human cells
Size:
20 ug
  $900.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence from TrueORF clone, RC209954, encoding the extracellular domain (Ser20 - Thr643) of human ERBB3
Tag C-DDK/His
Predicted MW 71 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS, pH 7.4, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001973
Locus ID 2065
UniProt ID P21860
Cytogenetics 12q13.2
RefSeq Size 5511
RefSeq ORF 4026
Synonyms c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK; HER3; LCCS2; MDA-BF-1; p45-sErbB3; p85-sErbB3; p180-ErbB3
Summary This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. provided by RefSeq, Jul 2008
Protein Categories ADC Targets, Diabetes, Enzyme: Kinases, Growth Factors, Intracellular Proteins, Membrane Proteins, Secreated Proteins
Protein Families Adult stem cells, Druggable Genome, Protein Kinase, Secreted Protein, Stem cell - Pluripotency, Transmembrane
Protein Pathways Calcium signaling pathway, Endocytosis, ErbB signaling pathway
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Other "ErbB 3" proteins (14)
SKU Description Size Price
PH309954 ERBB3 MS Standard C13 and N15-labeled recombinant protein (NP_001973) 10 ug
$3,360.00
PH324398 ERBB3 MS Standard C13 and N15-labeled recombinant protein (NP_001005915) 10 ug
$3,360.00
LC400725 Lyophilized ERBB3 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC423671 Lyophilized ERBB3 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC425161 Lyophilized ERBB3 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400725 Transient overexpression lysate of v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant 1 (as WB positive control) 100 ug
$436.00
LY423671 Transient overexpression lysate of v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant s (as WB positive control) 100 ug
$436.00
LY425161 Transient overexpression lysate of v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant s (as WB positive control) 100 ug
$436.00
TP309954 Recombinant protein of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant 1, 20 µg 20 ug
$867.00
TP324398 Recombinant protein of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant s, 20 µg 20 ug
$867.00
TP700106 Purified recombinant protein of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant 1, with C-terminal DDK/His tag, expressed in human cells, 20 µg 20 ug
$900.00
TP710089 Recombinant protein of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9, 20ug 20 ug
$540.00
TP710091 Recombinant protein of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant 1, residues 20-643, with C-terminal DDK tag, expressed in sf9, 20ug 20 ug
$540.00
TP723990 Recombinant Human HER3 protein with C-terminal 6×His tag 100 ug
$825.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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