Natriuretic peptides B (27-134, His-tag) Human Protein

SKU AR03036PU-L

Natriuretic peptides B (27-134, His-tag) human recombinant protein, 0.5 mg

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  MGSSHHHHHH SSGLVPRGSH MHPLGSPGSA SDLETSGLQE QRNHLQGKLS ELQVEQTSLE PLQESPRPTG VWKSREVATE GIRGHRKMVL YTLRAPRSPK MVQGSGCFGR KMDRISSSSG LGCKVLRRH
• Tag: His-tag
• Predicted MW: 14 kDa
• Concentration: lot specific
• Purity: >90% by SDS-PAGE
• Presentation State: Purified
• Buffer: Presentation State: Purified; State: Liquid purified protein; Buffer System: Phosphate-Buffered Saline (pH 7.4), 40% glycerol, 2 mM DTT, 0.1 mM PMSF, 1 mM EDTA
• Endotoxin: < 1.0 EU per 1 μg of protein (determined by LAL method)
• Preparation: Liquid purified protein
• Protein Description: Recombinant human BNP, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Storage: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice

Reference Data

• RefSeq: NP_002512
• Locus ID: 4879
• UniProt ID: P16860
• Cytogenetics: 1p36.22
• Synonyms: NPPB, Brain natriuretic peptide, BNP, proBNP
• Summary: This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]
• Protein Families: Druggable Genome, Secreted Protein, Stem cell - Pluripotency