RET (NM_020975) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC214268L4V
- LentiORF®
Lenti ORF particles, RET (mGFP-tagged)-Human ret proto-oncogene (RET), transcript variant 2, 200ul, >10^7 TU/mL
Lentiviral Particles: DDK DDK w/ Puro mGFP
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Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | mGFP |
Symbol | RET |
Synonyms | CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1 |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_020975 |
ORF Size | 3342 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC214268).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_020975.3 |
RefSeq Size | 5629 bp |
RefSeq ORF | 3345 bp |
Locus ID | 5979 |
UniProt ID | P07949 |
Cytogenetics | 10q11.21 |
Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
Protein Pathways | Endocytosis, Pathways in cancer, Thyroid cancer |
MW | 124.3 kDa |
Gene Summary | This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017] |
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