Eng (NM_001146350) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR222690L4V

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  • LentiORF®

Lenti ORF particles, Eng (GFP-tagged) - Mouse endoglin (Eng), transcript variant 2, 200ul, >10^7 TU/mL



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USD 1,092.00


Availability*
6 Weeks

Size
    • 200 ul


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Specifications

Product Data
Type Mouse Tagged ORF Clone
Tag mGFP
Symbol Eng
Synonyms AI528660; AI662476; CD105; Endo; S-endoglin
Mammalian Cell Selection Puromycin
Vector pLenti-C-mGFP-P2A-Puro
ACCN NM_001146350
ORF Size 1923 bp
Sequence Data
The ORF insert of this clone is exactly the same as(MR222690).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_001146350.1, NP_001139822.1
RefSeq Size 3572 bp
RefSeq ORF 1926 bp
Locus ID 13805
Cytogenetics 2 22.09 cM
Gene Summary Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:10625534). Required for normal structure and integrity of adult vasculature (By similarity). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (PubMed:10625534). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (PubMed:28530658). May play a role in the binding of endothelial cells to integrins. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity).[UniProtKB/Swiss-Prot Function]
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