Angiomotin (AMOT) (NM_001113490) Human Untagged Clone

CAT#: SC319022

AMOT (untagged)-Human angiomotin (AMOT), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: AMOT
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001113490, the custom clone sequence may differ by one or more nucleotides
  ATGAGAAATTCTGAAGAACAGCCAAGTGGAGGGACCACGGTATTGCAGCGTTTGCTACAA
  GAGCAGCTTCGCTATGGCAATCCTAGTGAGAATCGCAGCCTGCTTGCCATACACCAGCAA
  GCCACAGGGAATGGCCCTCCTTTCCCCAGTGGCAGTGGGAACCCGGGCCCTCAGAGTGAT
  GTGTTGAGTCCCCAAGACCACCACCAACAGCTTGTGGCTCATGCTGCTCGACAAGAACCC
  CAGGGGCAGGAAATCCAGTCAGAAAACCTCATCATGGAGAAGCAGCTGTCTCCTCGAATG
  CAAAATAATGAAGAACTCCCGACCTATGAAGAAGCCAAGGTCCAGTCCCAGTACTTTCGG
  GGCCAACAGCATGCCAGTGTTGGAGCTGCCTTCTATGTCACTGGAGTCACCAACCAGAAG
  ATGAGGACTGAGGGACGCCCATCAGTTCAGCGGCTCAATCCTGGAAAGATGCACCAAGAT
  GAGGGACTCAGAGACCTTAAGCAAGGGCATGTCCGTTCCTTGAGTGAACGACTAATGCAG
  ATGTCACTGGCCACCAGTGGAGTTAAGGCCCATCCACCTGTTACCAGTGCTCCCCTCTCC
  CCACCACAACCCAATGACCTCTACAAGAATCCCACAAGTTCCAGTGAATTCTACAAGGCC
  CAAGGGCCACTTCCTAACCAGCATAGCCTGAAGGGCATGGAACACCGAGGCCCCCCACCA
  GAATATCCCTTCAAGGGCATGCCACCCCAATCTGTAGTGTGCAAGCCCCAAGAGCCAGGG
  CACTTCTATAGTGAGCATCGCCTGAACCAGCCAGGGAGAACAGAGGGGCAACTGATGAGG
  TATCAGCATCCCCCTGAGTATGGAGCAGCCAGGCCAGCGCAGGACATCTCATTGCCATTG
  TCAGCCAGGAACTCGCAGCCTCACAGCCCTACTTCTTCTCTGACCTCTGGGGGGTCCTTG
  CCCTTGCTACAATCTCCACCATCCACTAGATTGTCTCCTGCCCGACACCCCTTGGTCCCA
  AACCAGGGAGACCATTCAGCTCACCTGCCTAGGCCGCAGCAGCATTTCCTTCCTAATCAG
  GCTCACCAGGGGGATCATTACCGTCTCTCCCAACCTGGCCTGAGTCAGCAGCAGCAGCAA
  CAGCAGCAGCAGCACCATCATCACCATCACCACCAACAACAGCAGCAGCAGCAGCCACAG
  CAGCAGCCAGGAGAAGCCTATTCAGCTATGCCTCGGGCTCAGCCATCCTCTGCTTCTTAT
  CAGCCAGTGCCAGCAGACCCTTTTGCCATTGTTTCCAGAGCCCAGCAGATGGTTGAGATC
  CTCTCAGACGAGAACCGGAACTTGAGGCAAGAGTTGGAAGGATGCTATGAGAAGGTGGCA
  AGACTGCAGAAGGTGGAGACAGAAATCCAGCGCGTCTCGGAGGCATATGAGAACCTCGTG
  AAGTCATCCTCCAAAAGAGAGGCCCTAGAGAAAGCCATGAGAAACAAGCTAGAGGGCGAG
  ATTCGGAGGATGCATGATTTCAACAGGGATCTGAGAGAGCGTCTAGAGACTGCCAACAAG
  CAGCTTGCAGAGAAGGAATATGAGGGGTCAGAGGACACCAGAAAAACCATCTCGCAGCTC
  TTTGCAAAAAATAAAGAAAGCCAGCGTGAGAAGGAGAAGCTGGAAGCGGAGCTGGCCACT
  GCCCGTTCTACCAATGAGGACCAAAGACGACACATCGAAATCCGAGATCAGGCCCTGAGT
  AATGCCCAGGCCAAGGTGGTAAAGCTGGAAGAAGAGCTGAAAAAGAAGCAAGTGTACGTT
  GACAAGGTGGAGAAGATGCAGCAGGCCCTTGTACAGCTCCAGGCAGCATGTGAAAAACGT
  GAGCAGCTAGAGCACCGTCTCCGGACACGACTGGAGAGGGAACTGGAATCCCTGAGAATC
  CAGCAGCGTCAGGGCAACTGTCAGCCCACCAACGTTTCAGAATACAATGCTGCTGCACTG
  ATGGAGCTCCTTCGGGAGAAAGAGGAGAGGATTCTGGCTCTGGAAGCTGATATGACAAAG
  TGGGAGCAGAAATATTTGGAGGAGAATGTGATGAGACATTTTGCTCTGGATGCTGCTGCA
  ACTGTGGCTGCTCAGAGGGACACAACAGTCATCAGTCACTCTCCTAACACCAGCTATGAC
  ACAGCTCTAGAAGCTCGCATCCAGAAAGAGGAGGAAGAAATCTTGATGGCCAATAAGCGT
  TGCCTTGACATGGAGGGCAGGATTAAGACCCTCCATGCCCAGATTATTGAGAAGGATGCC
  ATGATCAAAGTACTCCAGCAGCGTTCCCGGAAGGAGCCGAGCAAGACAGAGCAGCTGTCG
  TGCATGCGGCCAGCGAAGTCTCTGATGTCCATTTCCAATGCTGGATCAGGCTTGCTCTCC
  CACTCATCCACCCTGACTGGCTCCCCCATCATGGAAGAAAAGCGAGACGACAAGAGCTGG
  AAGGGGAGCCTAGGCATTCTCCTGGGTGGAGACTACCGTGCTGAATATGTCCCTTCCACA
  CCCTCGCCTGTGCCACCCTCGACTCCCCTGCTCTCGGCTCACTCCAAGACAGGCAGCCGA
  GACTGCAGTACCCAAACTGAACGTGGGACGGAATCGAACAAAACTGCAGCTGTTGCTCCC
  ATCTCTGTTCCTGCTCCAGTTGCTGCTGCCGCCACTGCTGCCGCCATCACTGCCACTGCT
  GCCACCATCACCACCACCATGGTAGCTGCTGCTCCAGTTGCTGTTGCTGCTGCTGCTGCT
  CCAGCTGCTGCTGCTGCCCCGTCTCCAGCCACTGCCGCTGCTACTGCTGCTGCTGTTTCT
  CCAGCTGCTGCTGGTCAGATTCCAGCTGCTGCCTCTGTTGCCTCAGCTGCTGCCGTTGCT
  CCTTCTGCTGCTGCTGCTGCTGCTGTTCAGGTTGCTCCAGCTGCTCCGGCTCCAGTTCCA
  GCTCCGGCTCTGGTTCCGGTTCCAGCTCCAGCAGCGGCTCAGGCTTCTGCTCCTGCTCAG
  ACTCAGGCACCAACTTCAGCTCCGGCTGTGGCTCCAACTCCAGCTCCAACTCCAACTCCA
  GCTGTGGCTCAGGCTGAGGTTCCTGCAAGTCCAGCTACCGGTCCTGGACCACATCGTTTG
  TCTATACCAAGTTTGACCTGCAATCCAGACAAAACAGATGGGCCTGTGTTCCACTCCAAT
  ACTCTGGAAAGAAAAACTCCCATTCAGATCCTGGGACAAGAGCCTGATGCAGAGATGGTG
  GAATATCTCATC
  
• Restriction Sites: Please inquire
• ACCN: NM_001113490
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001113490.1, NP_001106962.1
• RefSeq Size: 6945 bp
• RefSeq ORF: 3255 bp
• Locus ID: 154796
• UniProt ID: Q4VCS5
• Cytogenetics: Xq23
• Gene Summary: This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). The N-terminus of this isoform mediates association with cytoplasmic F-actin.