XBP1 (NM_005080) Human Untagged Clone
XBP1 (untagged)-Human X-box binding protein 1 (XBP1), transcript variant 1
|Product Name||XBP1 (NM_005080) Human Untagged Clone|
|Synonyms||TREB-5; TREB5; XBP-1; XBP2|
Fully Sequenced ORF
>OriGene ORF sequence for NM_005080 edited
|ORF Size||786 bp|
|OTI Disclaimer||Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at firstname.lastname@example.org or by calling 301.340.3188 option 3 for pricing and delivery.
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
|OTI Annotation||The open reading frame of this clone has been fully sequenced and found to be a perfect match to the protein associated with this reference, NM_005080.3.|
|Product Components||The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.|
|Protein Families||Transcription Factors|
|Gene Summary||This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform, XBP1(U).
|The use of this cDNA Clones has been cited in the following citations:|
NF?B Signaling is required for XBP1 (U and S) Mediated Effects on Antiestrogen Responsiveness and Cell Fate Decisions in Breast Cancer
,Hu, R;Warri, A;Jin, L;Zwart, A;Riggins, RB;Clarke, R;,
Mol. Cell. Biol. Nov 2014,PubMed ID 25368386
Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease
,Reinhardt, S;Schuck, F;Gr?sgen, S;Riemenschneider, M;Hartmann, T;Postina, R;Grimm, M;Endres, K;,
FASEB J. 2013 Nov 7,PubMed ID 24165480
|cDNA Clone Resources|
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