BIN1 (NM_139343) Human Untagged Clone
BIN1 (untagged)-Human bridging integrator 1 (BIN1), transcript variant 1
|Product Name||BIN1 (NM_139343) Human Untagged Clone|
|Synonyms||AMPH2; AMPHL; SH3P9|
Fully Sequenced ORF
>OriGene sequence for NM_139343 edited
|ORF Size||1782 bp|
|OTI Disclaimer||Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at email@example.com or by calling 301.340.3188 option 3 for pricing and delivery.
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
|OTI Annotation||The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.|
|Product Components||The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.|
|Gene Summary||This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016].
Transcript Variant: This variant (1) encodes the longest isoform, which is cytoplasmic. Isoform 1, also called IIa and S11R3-a, binds dynamin, synaptojanin, and clathrin. This isoform is expressed exclusively in the brain and is concentrated in nerve terminals.
|The use of this cDNA Clones has been cited in the following citations:|
Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain
,Sottejeau, Y;Bretteville, A;Cantrelle, FX;Malmanche, N;Demiaute, F;Mendes, T;Delay, C;Alves Dos Alves, H;Flaig, A;Davies, P;Dourlen, P;Dermaut, B;Laporte, J;Amouyel, P;Lippens, G;Chapuis, J;Landrieu, I;Lambert, JC;,
Acta Neuropathol Commun Sep 2015,PubMed ID 26395440
Bridging Integrator 1 (BIN1) Protein Expression Increases in the Alzheimer's Disease Brain and Correlates with Neurofibrillary Tangle Pathology
,Holler, CJ;Davis, PR;Beckett, TL;Platt, TL;Webb, RL;Head, E;Murphy, MP;,
J. Alzheimers Dis. July 2014,PubMed ID 25024306
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