FOXO3 (NM_201559) Human Untagged Clone

SKU SC308058

FOXO3 (untagged)-Human forkhead box O3 (FOXO3), transcript variant 2

Product Data

• Type: Human Untagged Clone
• Target Symbol: FOXO3
• Synonyms: AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_201559 edited; GCGCGAGGCCGTCGATTCGCTCGCGGCTCCATCGCGGCCTGGCCGGGGGGCGGTGTCTGC; TGCGCCAGGTTCGCTGGCCGCACGTCTTCAGGTCCTCCTGTTCCTGGGAGGCGGGCGCGG; CAGGACTGGGAGGTGGCGGCAGCGGGCGAGGACTCGCCGAGGACGGGGCTCCGGCCCGGG; ATAACCAACTCTCCTTCTCTCTTCTTTGGTGCTTCCCCAGGCGGCGGCGGCGGCGCCCGG; GAGCCGGAGCCTTCGCGGCGTCCACGTCCCTCCCCCGCTGCACCCCGCCCCGGCGCGAGA; GGAGAGCGCGAGAGCCCCAGCCGCGGGCGGGCGGGCGGCGAAGATGGCAGAGGCACCGGC; TTCCCCGGCCCCGCTCTCTCCGCTCGAAGTGGAGCTGGACCCGGAGTTCGAGCCCCAGAG; CCGTCCGCGATCCTGTACGTGGCCCCTGCAAAGGCCGGAGCTCCAAGCGAGCCCTGCCAA; GCCCTCGGGGGAGACGGCCGCTGACTCCATGATCCCCGAGGAGGAGGACGATGAAGACGA; CGAGGACGGCGGGGGACGGGCCGGCTCGGCCATGGCGATCGGCGGCGGCGGCGGGAGCGG; CACGCTGGGCTCCGGGCTGCTCCTTGAGGACTCGGCCCGGGTGCTGGCACCCGGAGGGCA; AGACCCCGGGTCTGGGCCAGCCACCGCGGCGGGCGGGCTGAGCGGGGGTACACAGGCGCT; GCTGCAGCCTCAGCAACCGCTGCCACCGCCGCAGCCGGGGGCGGCTGGGGGCTCCGGGCA; GCCGAGGAAATGTTCGTCGCGGCGGAACGCCTGGGGAAACCTGTCCTACGCGGACCTGAT; CACCCGCGCCATCGAGAGCTCCCCGGACAAACGGCTCACTCTGTCCCAGATCTACGAGTG; GATGGTGCGTTGCGTGCCCTACTTCAAGGATAAGGGCGACAGCAACAGCTCTGCCGGCTG; GAAGAACTCCATCCGGCACAACCTGTCACTGCATAGTCGATTCATGCGGGTCCAGAATGA; GGGAACTGGCAAGAGCTCTTGGTGGATCATCAACCCTGATGGGGGGAAGAGCGGAAAAGC; CCCCCGGCGGCGGGCTGTCTCCATGGACAATAGCAACAAGTATACCAAGAGCCGTGGCCG; CGCAGCCAAGAAGAAGGCAGCCCTGCAGACAGCCCCCGAATCAGCTGACGACAGTCCCTC; CCAGCTCTCCAAGTGGCCTGGCAGCCCCACGTCACGCAGCAGTGATGAGCTGGATGCGTG; GACGGACTTCCGTTCACGCACCAATTCTAACGCCAGCACAGTCAGTGGCCGCCTGTCGCC; CATCATGGCAAGCACAGAGTTGGATGAAGTCCAGGACGATGATGCGCCTCTCTCGCCCAT; GCTCTACAGCAGCTCAGCCAGCCTGTCACCTTCAGTAAGCAAGCCGTGCACGGTGGAACT; GCCACGGCTGACTGATATGGCAGGCACCATGAATCTGAATGATGGGCTGACTGAAAACCT; CATGGACGACCTGCTGGATAACATCACGCTCCCGCCATCCCAGCCATCGCCCACTGGGGG; ACTCATGCAGCGGAGCTCTAGCTTCCCGTATACCACCAAGGGCTCGGGCCTGGGCTCCCC; AACCAGCTCCTTTAACAGCACGGTGTTCGGACCTTCATCTCTGAACTCCCTACGCCAGTC; TCCCATGCAGACCATCCAAGAGAACAAGCCAGCTACCTTCTCTTCCATGTCACACTATGG; TAACCAGACACTCCAGGACCTGCTCACTTCGGACTCACTTAGCCACAGCGATGTCATGAT; GACACAGTCGGACCCCTTGATGTCTCAGGCCAGCACCGCTGTGTCTGCCCAGAATTCCCG; CCGGAACGTGATGCTTCGCAATGATCCGATGATGTCCTTTGCTGCCCAGCCTAACCAGGG; AAGTTTGGTCAATCAGAACTTGCTCCACCACCAGCACCAAACCCAGGGCGCTCTTGGTGG; CAGCCGTGCCTTGTCGAATTCTGTCAGCAACATGGGCTTGAGTGAGTCCAGCAGCCTTGG; GTCAGCCAAACACCAGCAGCAGTCTCCTGTCAGCCAGTCTATGCAAACCCTCTCGGACTC; TCTCTCAGGCTCCTCCTTGTACTCAACTAGTGCAAACCTGCCCGTCATGGGCCATGAGAA; GTTCCCCAGCGACTTGGACCTGGACATGTTCAATGGGAGCTTGGAATGTGACATGGAGTC; CATTATCCGTAGTGAACTCATGGATGCTGATGGGTTGGATTTTAACTTTGATTCCCTCAT; CTCCACACAGAATGTTGTTGGTTTGAACGTGGGGAACTTCACTGGTGCTAAGCAGGCCTC; ATCTCAGAGCTGGGTGCCAGGCTGAAGGATCACTGAGGAAGGGGAAGTGGGCAAAGCAGA; CCCTCAAACTGACACAAGACCTACAGAGAAAACCCTTTGCCAAATCTGCTCTCAGCAAGT; GGACAGTGATACCGTTTACAGCTTAACACCTTTGTGAATCCCACGCCATTTTCCTAACCC; AGCAGAGACTGTTAATGGCCCCTTACCCTGGGTGAAGCACTTACCCTTGGAACAGAACTC; TAAAAAGTATGCAAAATCTTCCTTGTACAGGGTGGTGAGCCGCCTGCCAGTGGAGGACAG; CACCCCTCAGCACCACCCACCCTCATTCAGAGCACACCGTGAGCCCCCGTCGGCCATTCT; GTGGTGTTTTAATATTGCGATGGTTTATGGGACGTTTTAAGTGTTGTTCTTGTGTTTGTT; TTCCTTTGACTTTCTGAGTTTTTCACATGCATTAACTTGCGGTATTTTTCTGTTAAAATG; TTAACCGTCCTTCCCCTAGCAAATTTAAAAACAGAAAGAAAATGTTGTACCAGTTACCAT; TCCGGGTTCGAGCATCACAAGCTTTTGAGCGCATGGAACTCCATAAACTAACAAATTACA; TAAACTAAAGGGGGATTTTCTTTCTTCTTTTGTTTGGTAGAAAATTATCCTTTTCTAAAA; ACTGAACAATGGCACAATTGTTTGCTATGTGCACCCGTCCAGGACAGAACCGTGCATAGG; CAAAAGGAGTGGAGCACAGCGTCCGGCCCAGTGTGTTTCCGGTTCTGAGTCAGGGTGATC; TGTGGACGGGACCCCAGCACCAAGTCTACGGGTGCCAGATCAGTAGGGCCTGTGATTTCC; TGTCAGTGTCCTCAGCTAATGTGAACAGTGTTGGTCTGCTGGTTAGAAACTAGAATATTG; ATATTTTCAGGAAAGAAATCAGCTCAGCTCTCCACTCATTGCCAAATGTCACTAAAGGGT; TTAGTTTTAAGGAGAAAGAAAAGGAAAAAAAAAAAAAA;
• Restriction Sites: Please inquire
• ACCN: NM_201559
• Insert Size: 3300 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_201559.1.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_201559.1, NP_963853.1
• RefSeq Size: 3311 bp
• RefSeq ORF: 2022 bp
• Locus ID: 2309
• UniProt ID: O43524
• Cytogenetics: 6q21
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Chemokine signaling pathway, Endometrial cancer, Neurotrophin signaling pathway, Non-small cell lung cancer
• Summary: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]; Transcript Variant: This variant (2) differs in the 5' end compared to variant 1. Both variants encode the same protein.