GDNF (NM_199234) Human Untagged Clone
GDNF (untagged)-Human glial cell derived neurotrophic factor (GDNF), transcript variant 3
|Product Name||GDNF (NM_199234) Human Untagged Clone|
|Synonyms||ATF1; ATF2; HFB1-GDNF; ATF2; HFB1-GDNF; astrocyte-derived trophic factor; glial cell line derived neurotrophic factor; glial derived neurotrophic factor; glial cell derived neurotrophic factor|
Fully Sequenced ORF
>OriGene sequence for NM_199234 edited
5' Read Nucleotide Sequence
>OriGene 5' read for NM_199234 unedited
|ORF Size||402 bp|
|OTI Disclaimer||Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).|
|OTI Annotation||The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.|
|Product Components||The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.|
|Protein Families||Secreted Protein, Transmembrane, Druggable Genome|
|Gene Summary||This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].
Transcript Variant: This variant (3) lacks an alternate segment in the 5' UTR and uses a downstream start codon, compared to variant 1. Isoform 3 has a shorter and distinct N-terminus, compared to isoform 1.
|cDNA Clone Resources|