SLC6A19 (NM_001003841) Human Untagged Clone

SKU SC300568

SLC6A19 (untagged)-Human solute carrier family 6 (neutral amino acid transporter), member 19 (SLC6A19)

Product Data

• Type: Human Untagged Clone
• Target Symbol: SLC6A19
• Synonyms: B0AT1; HND
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001003841 edited; ATGGTGAGGCTCGTGCTGCCCAACCCCGGCCTAGACGCCCGGATCCCGTCCCTGGCTGAG; CTGGAGACCATCGAGCAGGAGGAGGCCAGCTCCCGGCCGAAGTGGGACAACAAGGCGCAG; TACATGCTCACCTGCCTGGGCTTCTGCGTGGGCCTCGGCAACGTGTGGCGCTTCCCCTAC; CTGTGTCAGAGCCACGGAGGAGGAGCCTTCATGATCCCGTTCCTCATCCTGCTGGTCCTG; GAGGGCATCCCCCTGCTGTACCTGGAGTTCGCCATCGGGCAGCGGCTGCGGCGGGGCAGC; CTGGGTGTGTGGAGCTCCATCCACCCGGCCCTGAAGGGCCTAGGCCTGGCCTCCATGCTC; ACGTCCTTCATGGTGGGACTGTATTACAACACCATCATCTCCTGGATCATGTGGTACTTA; TTCAACTCCTTCCAGGAGCCTCTGCCCTGGAGCGACTGCCCGCTCAACGAGAACCAGACA; GGGTATGTGGACGAGTGCGCCAGGAGCTCCCCTGTGGACTACTTCTGGTACCGAGAGACG; CTCAACATCTCCACGTCCATCAGCGACTCGGGCTCCATCCAGTGGTGGATGCTGCTGTGC; CTGGCCTGCGCATGGAGCGTCCTGTACATGTGCACCATCCGCGGCATCGAGACCACCGGG; AAGGCCGTGTACATCACCTCCACGCTGCCCTATGTCGTCCTGACCATCTTCCTCATCCGA; GGCCTGACGCTGAAGGGCGCCACCAATGGCATCGTCTTCCTCTTCACGCCCAACGTCACG; GAGCTGGCCCAGCCGGACACCTGGCTGGACGCGGGCGCACAGGTCTTCTTCTCCTTCTCC; CTGGCCTTCGGGGGCCTCATCTCCTTCTCCAGCTACAACTCTGTGCACAACAACTGCGAG; AAGGACTCGGTGATTGTGTCCATCATCAACGGCTTCACATCGGTGTATGTGGCCATCGTG; GTCTACTCCGTCATTGGGTTCCGCGCCACACAGCGCTACGACGACTGCTTCAGCACGAAC; ATCCTGACCCTCATCAACGGGTTCGACCTGCCTGAAGGCAACGTGACCCAGGAGAACTTT; GTGGACATGCAGCAGCGGTGCAACGCCTCCGACCCCGCGGCCTACGCGCAGCTGGTGTTC; CAGACCTGCGACATCAACGCCTTCCTCTCAGAGGCCGTGGAGGGCACAGGCCTGGCCTTC; ATCGTCTTCACCGAGGCCATCACCAAGATGCCGTTGTCCCCACTGTGGTCTGTGCTCTTC; TTCATTATGCTCTTCTGCCTGGGGCTGTCATCTATGTTTGGGAACATGGAGGGCGTCGTT; GTGCCCCTGCAGGACCTCAGAGTCATCCCCCCGAAGTGGCCCAAGGAGGTGCTCACAGGC; CTCATCTGCCTGGGGACATTCCTCATTGGCTTCATCTTCACGCTGAACTCCGGCCAGTAC; TGGCTCTCCCTGCTGGACAGCTATGCCGGCTCCATTCCCCTGCTCATCATCGCCTTCTGC; GAGATGTTCTCTGTGGTCTACGTGTACGGTGTGGACAGGTTCAATAAGGACATCGAGTTC; ATGATCGGCCACAAGCCCAACATCTTCTGGCAAGTCACGTGGCGCGTGGTCAGCCCCCTG; CTCATGCTGATCATCTTCCTCTTCTTCTTCGTGGTAGAGGTCAGTCAGGAGCTGACCTAC; AGCATCTGGGACCCTGGCTACGAGGAATTTCCCAAATCCCAGAAGATCTCCTACCCGAAC; TGGGTGTATGTGGTGGTGGTGATTGTGGCTGGAGTGCCCTCCCTCACCATCCCTGGCTAT; GCCATCTACAAGCTCATCAGGAACCACTGCCAGAAGCCAGGGGACCATCAGGGGCTGGTG; AGCACACTGTCCACAGCCTCCATGAACGGGGACCTGAAGTACTGA;
• Restriction Sites: Please inquire
• ACCN: NM_001003841
• Insert Size: 1900 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001003841.1, NP_001003841.1
• RefSeq Size: 1905 bp
• RefSeq ORF: 1905 bp
• Locus ID: 340024
• UniProt ID: Q695T7
• Cytogenetics: 5p15.33
• Protein Families: Druggable Genome, Transmembrane
• Summary: This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene may result in Hartnup disorder, an inherited disease with symptoms such as pellagra, cerebellar ataxia, and psychosis. The expression and function of B0AT1 (SLC6A19) in intestinal cells depends on the presence of the accessory protein angiotensin-converting enzyme 2 (ACE2) which, among other functions, acts as a chaperone for membrane trafficking of B0AT1. The ACE2 is also the cellular receptor for severe acute respiratory syndrome-coronavirus (SARS-CoV) and for SARS-CoV-2 that is causing the coronavirus 2019 (COVID-19) pandemic [provided by RefSeq, Jul 2020]