C1S (NM_201442) Human Untagged Clone

SKU SC126504

C1S (untagged)-Human complement component 1, s subcomponent (C1S), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: C1S
• Synonyms: EDSPD2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC126504 sequence for NM_201442 edited (data generated by NextGen Sequencing); ATGTGGTGCATTGTCCTGTTTTCACTTTTGGCATGGGTTTATGCTGAGCCTACCATGTAT; GGGGAGATCCTGTCCCCTAACTATCCTCAGGCATATCCCAGTGAGGTAGAGAAATCTTGG; GACATAGAAGTTCCTGAAGGGTATGGGATTCACCTCTACTTCACCCATCTGGACATTGAG; CTGTCAGAGAACTGTGCGTATGACTCAGTGCAGATAATCTCAGGAGACACTGAAGAAGGG; AGGCTCTGTGGACAGAGGAGCAGTAACAATCCCCACTCTCCAATTGTGGAAGAGTTCCAA; GTCCCATACAACAAACTCCAGGTGATCTTTAAGTCAGACTTTTCCAATGAAGAGCGTTTT; ACGGGGTTTGCTGCATACTATGTTGCCACAGACATAAATGAATGCACAGATTTTGTAGAT; GTCCCTTGTAGCCACTTCTGCAACAATTTCATTGGTGGTTACTTCTGCTCCTGCCCCCCG; GAATATTTCCTCCATGATGACATGAAGAATTGCGGAGTTAATTGCAGTGGGGATGTATTC; ACTGCACTGATTGGGGAGATTGCAAGTCCCAATTATCCCAAACCATATCCAGAGAACTCA; AGGTGTGAATACCAGATCCGGTTGGAGAAAGGGTTCCAAGTGGTGGTGACCTTGCGGAGA; GAAGATTTTGATGTGGAAGCAGCTGACTCAGCGGGAAACTGCCTTGACAGTTTAGTTTTT; GTTGCAGGAGATCGGCAATTTGGTCCTTACTGTGGTCATGGATTCCCTGGGCCTCTAAAT; ATTGAAACCAAGAGTAATGCTCTTGATATCATCTTCCAAACTGATCTAACAGGGCAAAAA; AAGGGCTGGAAACTTCGCTATCATGGAGATCCAATGCCCTGCCCTAAGGAAGACACTCCC; AATTCTGTTTGGGAGCCTGCGAAGGCAAAATATGTCTTTAGAGATGTGGTGCAGATAACC; TGTCTGGATGGGTTTGAAGTTGTGGAGGGACGTGTTGGTGCAACATCTTTCTATTCGACT; TGTCAAAGCAATGGAAAGTGGAGTAATTCCAAACTGAAATGTCAACCTGTGGACTGTGGC; ATTCCTGAATCCATTGAGAATGGTAAAGTTGAAGACCCAGAGAGCACTTTGTTTGGTTCT; GTCATCCGCTACACTTGTGAGGAGCCATATTACTACATGGAAAATGGAGGAGGTGGGGAG; TATCACTGTGCTGGTAACGGGAGCTGGGTGAATGAGGTGCTGGGCCCGGAGCTGCCGAAA; TGTGTTCCAGTCTGTGGAGTCCCCAGAGAACCCTTTGAAGAAAAACAGAGGATAATTGGA; GGATCCGATGCAGATATTAAAAACTTCCCCTGGCAAGTCTTCTTTGACAACCCATGGGCT; GGTGGAGCGCTCATTAATGAGTACTGGGTGCTGACGGCTGCTCATGTTGTGGAGGGAAAC; AGGGAGCCAACAATGTATGTTGGGTCCACCTCAGTGCAGACCTCACGGCTGGCAAAATCC; AAGATGCTCACTCCTGAGCATGTGTTTATTCATCCGGGATGGAAGCTGCTGGAAGTCCCA; GAAGGACGAACCAATTTTGATAATGACATTGCACTGGTGCGGCTGAAAGACCCAGTGAAA; ATGGGACCCACCGTCTCTCCCATCTGCCTACCAGGCACCTCTTCCGACTACAACCTCATG; GATGGGGACCTGGGACTGATCTCAGGCTGGGGCCGAACAGAGAAGAGAGATCGTGCTGTT; CGCCTCAAGGCGGCAAGGTTACCTGTAGCTCCTTTAAGAAAATGCAAAGAAGTGAAAGTG; GAGAAACCCACAGCAGATGCAGAGGCCTATGTTTTCACTCCTAACATGATCTGTGCTGGA; GGAGAGAAGGGCATGGATAGCTGTAAAGGGGACAGTGGTGGGGCCTTTGCTGTACAGGAT; CCCAATGACAAGACCAAATTCTACGCAGCTGGCCTGGTGTCCTGGGGGCCCCAGTGTGGG; ACCTATGGGCTCTACACACGGGTAAAGAACTATGTTGACTGGATAATGAAGACTATGCAG; GAAAATAGCACCCCCCGTGAGGACTAA; ; Clone variation with respect to NM_201442.2;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_201442 unedited; TGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCTCGGGTAGGGAATCT; TATGAACAGAACCAGGACAGGGAGGCTGGCCGGAGGTTCCTGCAGAGGGAGCGTCAAGGC; CCTGTGCTGCTGTCCCTGGGGGCCAGAGGGGTTGCCCAGCATGCCCACTGGCAGGAGAGA; GGGAACTGACCCACTTGCTCCTACCAGCTTCTGAAGGTGACACTGAGCCCCAGGTGACGC; CGCACCACCAAAGAAGGTGCTTGTGTTTGTCAGACAAATACAGCCAGGCCTGCCACCCCT; TAGGCTCCAAAGTCCGGAGGTGCAGAAAGCCAGGACCAAGAGACAGGCAGCTCACCAGGG; TGGACAAATCGCCAGAGATGTGGTGCATTGTCCTGTTTTCACTTTTGGCATGGGTTTATG; CTGAGCCTACCATGTATGGGGAGATCCTGTCCCCTAACTATCCTCAGGCATATCCCAGTG; AGGTAGAGAAATCTTGGGACATAGAAGTTCCTGAAGGGTATGGGATTCACCTCTACTTCA; CCCATCTGGACATTGAGCTGTCAGAGAACTGTGCGTATGACTCAGTGCAGATAATCTCAG; GAGACACTGAAGAANGGAGGCTCTGTGGACAGAGGAGCAGTAACAATCCCCACTCTCCAA; TTGTGGAAGAGTTCCCAGTCCCATACCACANACTCCAGGTGATCTTTAAGTCAGACTTTT; TCCATGAAGAGCGTTNTACGGGGTTTGCTGCATACTATGTTGCCACAGACATAAATGAAT; GCACAGATTNNTGTAGATGTCCCCTTGTACCCCACTTCTGCACAATTTCATTGGTGGTTA; CCTTCTGCTNCCGGCCCCCCGAATATTTCCTCCATGATGACATGAAGAATGGCCGGAGTA; AATGCAGTGGGGATTGGATCAC;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_201442 unedited; CTATGGAACGCGGCACGCTTTCTAAAGTCGAGTTTTTTTTTTTTTTTTTTGCTTATAAAC; ATCCTTTATTGTACATAGACAGTGGATACTGAGAATGATCAAGTAAATGGAATTTTGAAC; AGGTAAAGAGGAAACAAAGAATTAAGGTATCCCTGTGGAATAGTGCAAGAAAGGAGTGCC; CCACCCATAGTGTTATCTACAATAGGTACTCCGGGGAAAGGACCCCAAGGAGTCAGACCA; CAAATGTATGACCAGCACAATTCTATGATCAAACTCTACCTCTAGCAAGGCGTCTCAACA; ATCAAGTTCTATTTAAATCATTCGCTCGTGTCTTCTTTCAGTCATGATGAAATAATGAGA; ATATCATAAGGAACAGAAGGTAATGCATTGGTCACCACCCTTGGAGAGGCTGGTGGGATG; TATCTGGATTAGTCCTCACGGGGGGTGCTATTTTCCTGCATAGTCTTCATTATCCAGTCA; ACATAGTTCTTTACCCGTGTGTAGAGCCCATAGGTCCCACACTGGGGCCCCCAGGACACC; AGGCCAGCTGCGTAGAATTTGGTCTTGTCATTGGGATCCTGTACAGCAAAGGCCCCACCA; CTGTCCCCTTTACAGCTATCCATGCCCTTCTCTCCTCCAGCACAGATCATGTTAGGAGTG; AAAACATAAGCCTCTGCATCTGCTGTGGGTTTCTCCACTTTCACTTCTTTGCATTTTCTT; AAAGGAGCTACAGGTAACCTTGCCGCCTTGAAGCGAACAGCACGATCTCTCTTCTCTGTT; CGGCCCCAGCCTGAGATCAGTCCCAGGTCCCATCCATGAGTTGTANTCGGAAAAAGTGCC; TGTAAGCACATGGAAGATACGTGGGGTCCATTTTCACTGGGTCTTTCAGCCGCACCATGC; AATGTCATATCAAAATGGNTCGTCCTTCGGGACTTCACAGCTTCCTCCCGGTGAATTACC; ATGCTCAGGATGAGCTCTGGATTTG;
• Restriction Sites: NotI-NotI
• ACCN: NM_201442
• Insert Size: 2900 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_201442.1, NP_958850.1
• RefSeq Size: 2813 bp
• RefSeq ORF: 2067 bp
• Locus ID: 716
• UniProt ID: P09871
• Cytogenetics: 12p13.31
• Protein Families: Druggable Genome, Protease
• Protein Pathways: Complement and coagulation cascades, Systemic lupus erythematosus
• Summary: This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]; Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).