CBX6 (NM_014292) Human Untagged Clone

CAT#: SC123837

CBX6 (untagged)-Human chromobox homolog 6 (CBX6)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CBX6
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_014292 edited
  GGCTGTGGGTGCCGCTGAGCAAGATGGAGCTGTCTGCAGTGGGCGAGCGGGTCTTCGCGG
  CCGAATCCATCATCAAACGGCGGATCCGAAAGGGACGCATCGAGTACCTGGTGAAATGGA
  AGGGGTGGGCGATCAAGTACAGCACTTGGGAGCCCGAGGAGAACATCCTGGACTCGCGGC
  TCATTGCAGCCTTCGAACAAAAGGAGAGGGAGCGTGAGCTGTATGGGCCCAAGAAGAGGG
  GACCCAAACCCAAAACTTTCCTCCTGAAGGCGCGGGCCCAGGCCGAGGCCCTCCGCATCA
  GTGATGTGCATTTCTCTGTCAAGCCGAGCGCCAGTGCCTCCTCGCCCAAGCTGCACTCCA
  GCGCAGCCGTGCACCGGCTCAAGAAGGACATCCGCCGCTGCCACCGTATGTCCCGCCGTC
  CCCTGCCCCGCCCGGACCCGCAGGGGGGCAGCCCCGGACTGCGCCCGCCCATTTCGCCCT
  TCTCGGAGACGGTGCGCATCATCAACCGCAAGGTGAAGCCGCGGGAGCCCAAGCGGAACC
  GCATCATCCTGAACCTGAAGGTGATCGACAAGGGCGCTGGCGGCGGGGGCGCCGGGCAGG
  GGGCCGGGGCGCTGGCCCGCCCCAAAGTCCCCTCGCGGAACCGCGTTATAGGCAAGAGCA
  AGAAGTTCAGCGAGAGCGTCCTGCGTACACAGATCCGCCACATGAAGTTCGGCGCCTTTG
  CGCTGTACAAGCCTCCGCCCGCCCCCCTGGTAGCCCCGTCCCCCGGCAAGGCTGAGGCCT
  CAGCCCCGGGCCCTGGGCTACTTCTGGCCGCCCCCGCCGCCCCCTACGACGCCCGCAGCT
  CTGGCTCCTCCGGCTGCCCCTCGCCTACACCACAGTCCTCTGACCCCGACGACACGCTCC
  CCAAGCTCCTCCCCGAGACCGTGAGCCCATCCGCCCCCAGCTGGCGCGAGCCGGAGGTGC
  TCGACCTGTCCCTCCCTCCCGAGTCGGCAGCCACCAGCAAGCGGGCACCGCCTGAGGTCA
  CAGCTGCTGCCGGCCCGGCACCTCCCACGGCCCCTGAGCCCGCCGGTGCCTCCTCCGAGC
  CCGAGGCTGGGGACTGGCGCCCCGAGATGTCACCCTGCTCCAATGTGGTCGTCACCGATG
  TCACCAGCAACCTCCTGACGGTCACAATCAAGGAATTCTGCAACCCTGAGGATTTCGAGA
  AGGTGGCTGCTGGGGTAGCAGGCGCCGCTGGGGGCGGTGGCAGCATTGGGGCGAGCAAGT
  GAGGGGGCTCCACCAAGGAGGGGGGCTTGGGGGGGCCCTCCTGCCCGAAGTCATACTCTT
  GCTCCCACCCCACCCTTGCCCCCAGCCCTCTCTCCCTGTGCTTTGCTTGTCTCAAATGGC
  TCGGTGTTGACCCAGGGATGGGGCTGGGTAGTTGGGGTCCCAGAAAGCCGGGGGTAGGGG
  CCACCCTGGAATGGGGCAGGGGAAGGGCACACCCCCTGCCCATGCATGGTAGCCCACTGG
  GTGGTTTCTGGAAAGCCCTAGAAACTAGGGTTCCTCTGCCCCTTCCACATCCCACCTGTC
  TCTCTAGCTTGCTTCCTGCTCTCCTGTGCGGCGTCTGATTTCTCGGTGCTAACCTGGCAG
  CTGTGGGGCCCTTAGGAGCCCCCCACCGAGGGTGGACACAGTCCCTTTCCTTCCTGCAGA
  TGCCTAGGCAGGAGGAGGGCTTCCTGCCTGTTTGGCAAAGTCCCAGGCAGAGGCCAAGGA
  TGAGGCCTGACTCGGCTCCTCCCTCCACATCAGCCAGGGCATCAGAAGTTGGGCCAGGGC
  GGGGTCTTCCCTGCTCGATTTTGGACGAGGCCTAAGTAGACCCCCTATGCCCTGCCCCAG
  CCCTGGCTCTTTCCTAACCCCCTCAACGGTGGGAGGAACTGGCAGAGGGTGCGCCTGGCC
  ACAGCCTCCCCGCATCTAAAGGCCCCTTCAGTTCTTGACCAAAGGTGCTACGAGAACCTG
  CCGTGGAAACTTCCAGTTGTGCGTCTGCCCCACTCGCTGTGTTTGTCCGTGGGTTCATAC
  ATGCATTGGGTGCTAGGCCCCAGGCTGCCGGGTGGCACCCTTTACAGTTCCTTTGAACAG
  GGGCATTGAAGGCCTGGACTGCCTCTCGCCTCAGTAGGCCTGGGGACCAGGCTTGGGTCT
  GGAGGTTTGCTGTGGAAGTCACCAGGCCTCCCCTCCTGGCCCAGGTGTGCTGGGGGCACC
  GTGCCCCCCACCCCCCTGCCCTCCTCAGGGTGGTCAGCCCAACCTGTCGGACCTTCACTT
  CACATCATGGTGGGGACCGAGATAGAGAGGGAGACCCCATTCCAAGCTCCCTCTTCCTCC
  CGGTGTTTGGGGAGGATGCTGAAGAATCCATTCCCGAGGGCCTCCCGGCTTGTCCCAGCC
  CCTCTTTTGCTTCTGACCACGGAGGCTTTCTCACAGCCCAGCCTGCCTGAAGCAAAGGAG
  GCTCCCGTGTCCTGGGCAGCTTCTGTTTCCCTCTGCTGCCTGGGAGCTGAGGCACCCGTG
  CCAGTGGCAGAGGCCACAGCCCCAGCCTTAGGCCAGGCCCTGGGAGGGCAGGCAGGCAAA
  GGGGAGACCAGAGGGTCTGTGTTCTCCAGGAGAATGAGGGTGTTGGTCCCAGAATTGGGA
  CCGGGGCCCCGCTGGCCAGCCCTGGGCCACTTCCCGGGTCTCCATTGTGCGTGGGTGGCG
  TGTTCCAGGCGTGGCTGGAGCTGGCTTCCTGGCTGTGCTGCCATGGGCCCCTCCCTCAGA
  AGCACGTTGGCAGGAGGCCGATCAGAACCCTAGCGCCTTTGGTCCTAAGAATGGGAGGCT
  GCCTTCCTTCCCAATCTCCCTGCCAGGGCCCACAGCGTGGCCCTAGCCCTCCCCTCCCCG
  GGATGTAGAACGGGGACCCTCGCAGGGTTGGGGCGGGGGCTGATACTCCTCGGCCCCTCC
  CTACCCTGCCCTGTGTGTTGGCTTTGTGGCCGTCCAAGTGCCAATTGGCTTTTCGCCCAA
  ATAAGGGCTGGTATTTCTCCTCTGTCCTTGGAGGTGATTTCCCCCTGACCCCCTCCCCCA
  GGTGAGTGACCACCTGGGTGCCAGTTACAGGTGTTTCCAGAGACCATAGAAATGTGTTTT
  CCTGAGAGTTCGTGTCATTCGTGACTTTTTTGTAAAGAAGTTGTGTTTTCAGAGGTGATT
  TTATGACAGGAAAGTGAAAGAATTAGTTTTGCAAAAAAACAAAAACAAAAAAAAAAAAAA
  AAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014292 unedited
  AAAAAACCGTACAGGATTTTGTAAACGACTTACTATAGGCGGCCGCGNAATTCGCACGAG
  GGGCTGTGGGTGCCGCTGAGCAAGAGGAGCTGTCTGCAGTGGGCGAGCGGGTCTTCGCGG
  CCGAATCCATCATCAAACGGCGGATCCGAAAGGGACGCATCGAGTACCTGGTGAAATGGA
  AGGGGTGGGCGATCAAGTACAGCACTTGGGAGCCCGAGGAGAACATCCTGGACTCGCGGC
  TCATTGCAGCCTTCGAACAAAAGGAGAGGGAGCGTGAGCTGTATGGGCCCAAGAAGAGGG
  GACCCAAACCCAAAACTTTCCTCCTGAAGGCGCGGGCCCAGGCCGAGGCCCTCCGCATCA
  GTGATGTGCATTTCTCTGTCAAGCCGAGCGCCAGTGCCTCCTCGCCCAAGCTGCACTCCA
  GCGCAGCCGTGCACCGGCTCAAGAAGGACATCCGCCGCTGCCACCGTATGTCCCGCCGTC
  CCCTGCCCCGCCCGGACCCGCAGGGGGGCAGCCCCGGACTGCGCCCGCCCATTTCGCCCT
  TCTCGGAGACGGTGCGCATCATCAACCGCAAGGTGAAGCCGCGGGAGCCCAAGCGGAACC
  GCATCATCCTGAACCTGAAGGTGATCGACAAGGCGCTGGGCGGGCNGTNNNNNNNNGGCN
  NNTGGCNNGGGGNCCCGGGNNGGCCNCTTNCGGCCCGGCGCGGGCCCNCGCCCCCCGCGN
  CCGCGGGGAACCCGGGGAGGGGCCCCGGGCTGGGCCGGGTGCGCCCCGGGCCCNNTTCTG
  GCTCTTNCTCCTTTTTTTCCTGGGGCGGATCCCGCTGTTTTGGGTTTCCCCTTTGCCGGG
  CTGGGCCTCCCGGGGCCGGGCCCTGGGCTTGTTGCGGGGCGCCCCTGCTA
  
• Restriction Sites: Please inquire
• ACCN: NM_014292
• Insert Size: 2500 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_014292.3, NP_055107.3
• RefSeq Size: 3284 bp
• RefSeq ORF: 1239 bp
• Locus ID: 23466
• UniProt ID: O95503
• Cytogenetics: 22q13.1
• Protein Families: Transcription Factors
• Gene Summary: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity).[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.