CCR3 (NM_178329) Human Untagged Clone

CAT#: SC123356

CCR3 (untagged)-Human chemokine (C-C motif) receptor 3 (CCR3), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CCR3
• Synonyms: CC-CKR-3; C C CKR3; CD193; CKR 3; CKR3; CMKBR3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_178329 edited
  TGCTGGGCGAATCCCTTTCTTGTCTGGTTCATTTGGACCCTCCAAAGCCCACAGGCTGGA
  ACGGCTGAGTCATCCAAACAAAAAAGGTGGCAGCCCATCCCTCCCCCAGGAGCTCTACCC
  TGTCTCAAGTAGGTGCTACCCTGTTGCTGGTGGCTGGCTGGAATTCCAAGCCAGTTGATC
  TTATCCTGTGAGGTCCCTTGGAAGTGGGGCCCACAGACTGACGCTGCTCTGCTTCCTGGA
  TTCAGCCCTCTTCCTAAGGAGCTCATGGACCCTGGCCGTCATCAGGTTCAACCTCATATT
  CAACTGCTGGGCCTTGTCTTCTGGCCACACACTCTCTCCAAATCAGCGATGGTGGGGAAC
  TGAGGAGCCAGAGGCCATTGTGGAAGAACTCCAAGAAAACAATCTCCAGGTTATCACATC
  TAAAGCCTGAGCAAGATTTGAGGCTGGGAAGAGGTGGATCCCAGAATTGGAAGAAGGAGT
  GGTGATGCCTAAGCTATCACTGGACATATCAAGGACTTCACTAAATTAGCAGGGAGAAGT
  GAAATGACAACCTCACTAGATACAGTTGAGACCTTTGGTACCACATCCTACTATGATGAC
  GTGGGCCTGCTCTGTGAAAAAGCTGATACCAGAGCACTGATGGCCCAGTTTGTGCCCCCG
  CTGTACTCCCTGGTGTTCACTGTGGGCCTCTTGGGCAATGTGGTGGTGGTGATGATCCTC
  ATAAAATACAGGAGGCTCCGAATTATGACCAACATCTACCTGCTCAACCTGGCCATTTCG
  GACCTGCTCTTCCTCGTCACCCTTCCATTCTGGATCCACTATGTCAGGGGGCATAACTGG
  GTTTTTGGCCATGGCATGTGTAAGCTCCTCTCAGGGTTTTATCACACAGGCTTGTACAGC
  GAGATCTTTTTCATAATCCTGCTGACAATCGACAGGTACCTGGCCATTGTCCATGCTGTG
  TTTGCCCTTCGAGCCCGGACTGTCACTTTTGGTGTCATCACCAGCATCGTCACCTGGGGC
  CTGGCAGTGCTAGCAGCTCTTCCTGAATTTATCTTCTATGAGACTGAAGAGTTGTTTGAA
  GAGACTCTTTGCAGTGCTCTTTACCCAGAGGATACAGTATATAGCTGGAGGCATTTCCAC
  ACTCTGAGAATGACCATCTTCTGTCTCGTTCTCCCTCTGCTCGTTATGGCCATCTGCTAC
  ACAGGAATCATCAAAACGCTGCTGAGGTGCCCCAGTAAAAAAAAGTACAAGGCCATCCGG
  CTCATTTTTGTCATCATGGCGGTGTTTTTCATTTTCTGGACACCCTACAATGTGGCTATC
  CTTCTCTCTTCCTATCAATCCATCTTATTTGGAAATGACTGTGAGCGGAGCAAGCATCTG
  GACCTGGTCATGCTGGTGACAGAGGTGATCGCCTACTCCCACTGCTGCATGAACCCGGTG
  ATCTACGCCTTTGTTGGAGAGAGGTTCCGGAAGTACCTGCGCCACTTCTTCCACAGGCAC
  TTGCTCATGCACCTGGGCAGATACATCCCATTCCTTCCTAGTGAGAAGCTGGAAAGAACC
  AGCTCTGTCTCTCCATCCACAGCAGAGCCGGAACTCTCTATTGTGTTTTAGGTCAGATGC
  AGAAAATTGCCTAAAGAGGAAGGACCAAGGAGATGAAGCAAACACATTAAGCCTTCCACA
  CTCACCTCTAAAACAGTCCTTCAAACTTCCAGTGCAACACTGAAGCTCTTGAAGACACTG
  AAATATACACACAGCAGTAGCAGTAGATGCATGTACCCTAAGGTCATTACCACAGGCCAG
  GGGCTGGGCAGCGTACTCATCATCAACCCTAAAAAGCAGAGCTTTGCTTCTCTCTCTAAA
  ATGAGTTACCTACATTTTAATGCACCTGAATGTTAGATAGTTACTATATGCCGCTACAAA
  AAGGTAAAACTTTTTATATTTTATACATTAACTTCAGCCAGCTATTGATATAAATAAAAC
  ATTTTCACACAATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_178329 unedited
  GGGGACGTTTGGATTTTGTAATACGACTTACTATAGGGNNCGGCCGCGCAATTCCAAGCC
  AGTTGATCTTATCCTGTGAGGTCCCTTGGAAGTGGGGCCCACAGACTGACGCTGCTCTGC
  TTCCTGGATTCAGCCCTCTTCCTAAGGAGCTCATGGACCCTGGCCGTCATCAGGTTCAAC
  CTCATATTCAACTGCTGGGCCTTGTCTTCTGGCCACACACTCTCTCCAAATCAGCGATGG
  TGGGGAACTGAGGAGCCAGAGGCCATTGTGGAAGAACTCCAAGAAAACAATCTCCAGGTT
  ATCACATCTAAAGCCTGAGCAAGATTTGAGGCTGGGAAGAGGTGGATCCCAGAATTGGAA
  GAAGGAGTGGTGATGCCTAAGCTATCACTGGACATATCAAGGACTTCACTAAATTAGCAG
  GGAGAAGTGAAATGACAACCTCACTAGATACAGTTGAGACCTTTGGTACCACATCCTACT
  ATGATGACGTGGGCCTGCTCTGTGAAAAAGCTGATACCAGAGCACTGATGGCCCAGTTTG
  TGCCCCCGCTGTACTCCCTGGTGTTCACTGTGGGCCTCTTNGGCAATGTGGTGGTGGTGA
  TGATCCTCATAAAATACAGGAGGCTCCGAATTATGACCAACATCTACCTGCTCAACCTGG
  CCATTTCGGACCTGCTCTTCCTCGTCACCCTTCCATTCTGGATCCACTATGTCAGGGGGC
  ATAACTGGGTTTTTGGCCATGGCATGTGTAAGCTCCTCTCAAGGTTTATCACACAGGCTT
  GTACAGCGAGATCCTTTTTCATATCCTGCTGACAATCGACAGGTACCTGGCCATTTGTCA
  TGCTGTGTTTGCCCTTCAAGCCCGACTGTCACTTTTGGTGTCATCACCAGCATCTTCACC
  TGG
  
• Restriction Sites: Please inquire
• ACCN: NM_178329
• Insert Size: 2030 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_178329.1, NP_847899.1
• RefSeq Size: 1866 bp
• RefSeq ORF: 1068 bp
• Locus ID: 1232
• UniProt ID: P51677
• Cytogenetics: 3p21.31
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction
• Gene Summary: The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
  Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, as compared to variant 1. Both variants encode the same isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.