Integrin beta 7 (ITGB7) (NM_000889) Human Untagged Clone

CAT#: SC119589

ITGB7 (untagged)-Human integrin, beta 7 (ITGB7)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Integrin beta 7
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_000889 edited
  GAATTCGGCACGAGGCAGAGGAAGGACTGCTCTGCACGCACCTATGTGGAAACTAAAGCC
  CAGAGAGAAAGTCTGACTTGCCCCACAGCCAGTGAGTGACTGCAGCAGCACCAGAATCTG
  GTCTGTTTCCTGTTTGGCTCTTCTACCACTACGGCTTGGGATCTCGGGCATGGTGGCTTT
  GCCAATGGTCCTTGTTTTGCTGCTGGTCCTGAGCAGAGGTGAGAGTGAATTGGACGCCAA
  GATCCCATCCACAGGGGATGCCACAGAATGGCGGAATCCTCACCTGTCCATGCTGGGGTC
  CTGCCAGCCAGCCCCCTCCTGCCAGAAGTGCATCCTCTCACACCCCAGCTGTGCATGGTG
  CAAGCAACTGAACTTCACCGCGTCGGGAGAGGCGGAGGCGCGGCGCTGCGCCCGACGAGA
  GGAGCTGCTGGCTCGAGGCTGCCCGCTGGAGGAGCTGGAGGAGCCCCGCGGCCAGCAGGA
  GGTGCTGCAGGACCAGCCGCTCAGCCAGGGCGCCCGCGGAGAGGGTGCCACCCAGCTGGC
  GCCGCAGCGGGTCCGGGTCACGCTGCGGCCTGGGGAGCCCCAGCAGCTCCAGGTCCGCTT
  CCTTCGTGCTGAGGGATACCCGGTGGACCTGTACTACCTTATGGACCTGAGCTACTCCAT
  GAAGGACGACCTGGAACGCGTGCGCCAGCTCGGGCACGCTCTGCTGGTCCGGCTGCAGGA
  AGTCACCCATTCTGTGCGCATTGGTTTTGGTTCCTTTGTGGACAAAACGGTGCTGCCCTT
  TGTGAGCACAGTACCCTCCAAACTGCGCCACCCCTGCCCCACCCGGCTGGAGCGCTGCCA
  GTCACCATTCAGCTTTCACCATGTGCTGTCCCTGACGGGGGACGCACAAGCCTTCGAGCG
  GGAGGTGGGGCGCCAGAGTGTGTCCGGCAATCTGGACTCGCCTGAAGGTGGCTTCGATGC
  CATTCTGCAGGCTGCACTCTGCCAGGAGCAGATTGGCTGGAGAAATGTGTCCCGGCTGCT
  GGTGTTCACTTCAGACGACACATTCCATACAGCTGGGGACGGGAAGTTGGGCGGCATTTT
  CATGCCCAGTGATGGGCACTGCCACTTGGACAGCAATGGCCTCTACAGTCGCAGCACAGA
  GTTTGACTACCCTTCTGTGGGTCAGGTAGCCCAGGCCCTCTCTGCAGCAAATATCCAGCC
  CATCTTTGCTGTCACCAGTGCCGCACTGCCTGTCTACCAGGAGCTGAGTAAACTGATTCC
  TAAGTCTGCAGTTGGGGAGCTGAGTGAGGACTCCAGCAACGTGGTACAGCTCATCATGGA
  TGCTTATAATAGCCTGTCTTCCACCGTGACCCTTGAACACTCTTCACTCCCTCCTGGGGT
  CCACATTTCTTACGAATCCCAGTGTGAGGGTCCTGAGAAGAGGGAGGGTAAGGCTGAGGA
  TCGAGGACAGTGCAACCACGTCCGAATCAACCAGACGGTGACTTTCTGGGTTTCTCTCCA
  AGCCACCCACTGCCTCCCAGAGCCCCATCTCCTGAGGCTCCGGGCCCTTGGCTTCTCAGA
  GGAGCTGATTGTGGAGTTGCACACGCTGTGTGACTGTAATTGCAGTGACACCCAGCCCCA
  GGCTCCCCACTGCAGTGATGGCCAGGGACACCTACAATGTGGTGTATGCAGCTGTGCCCC
  TGGCCGCCTAGGTCGGCTCTGTGAGTGCTCTGTGGCAGAGCTGTCCTCCCCAGACCTGGA
  ATCTGGGTGCCGGGCTCCCAATGGCACAGGGCCCCTGTGCAGTGGAAAGGGTCACTGTCA
  ATGTGGACGCTGCAGCTGCAGTGGACAGAGCTCTGGGCATCTGTGCGAGTGTGACGATGC
  CAGCTGTGAGCGACATGAGGGCATCCTCTGCGGAGGCTTTGGTCGCTGCCAATGTGGAGT
  ATGTCACTGTCATGCCAACCGCACGGGCAGAGCATGCGAATGCAGTGGGGACATGGACAG
  TTGCATCAGTCCCGAGGGAGGGCTCTGCAGTGGGCATGGACGCTGCAAATGCAACCGCTG
  CCAGTGCTTGGACGGCTACTATGGTGCTCTATGCGACCAATGCCCAGGCTGCAAGACACC
  ATGCGAGAGACACCGGGACTGTGCAGAGTGTGGGGCCTTCAGGACTGGCCCACTGGCCAC
  CAACTGCAGTACAGCTTGTGCCCATACCAATGTGACCCTGGCCTTGGCCCCTATCTTGGA
  TGATGGCTGGTGCAAAGAGCGGACCCTGGACAACCAGCTGTTCTTCTTCTTGGTGGAGGA
  TGACGCCAGAGGCACGGTCGTGCTCAGAGTGAGACCCCAAGAAAAGGGAGCAGACCACAC
  GCAGGCCATTGTGCTGGGCTGCGTAGGGGGCATCGTGGCAGTGGGGCTGGGGCTGGTCCT
  GGCTTACCGGCTCTCGGTGGAAATCTATGACCGCCGGGAATACAGTCGCTTTGAGAAGGA
  GCAGCAACAACTCAACTGGAAGCAGGACAGTAATCCTCTCTACAAAAGTGCCATCACGAC
  CACCATCAATCCTCGCTTTCAAGAGGCAGACAGTCCCACTCTCTGAAGGAGGGAGGGACA
  CTTACCCAAGGCTCTTCTCCTTGGAGGACAGTGGGAACTGGAGGGTGAGAGGAAGGGTGG
  GTCTGTAAGACCTTGGTAGGGGACTAATTCACTGGCGAGGTGCGGCCACCACCCTACTTC
  ATTTTCAGAGTGACACCCAAGAGGGCTGCTTCCCATGCCTGCAACCTTGCATCCATCTGG
  GCTACCCCACCCAAGTATACAATAAAGTCTTACCTCAGAAAAAAAAAAAAAAAAAAAAAA
  CTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000889 unedited
  ATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCAGAGGAAGGACTGCTCTGC
  ACGCACCTATGTGGAAACTAAAGCCCAGAGAGAAAGTCTGACTTGCCCCACAGCCAGTGA
  GTGACTGCAGCAGCACCAGAATCTGGTCTGTTTCCTGTTTGGCTCTTCTACCACTACGGC
  TTGGGATCTCGGGCATGGTGGCTTTGCCAATGGTCCTTGTTTTGCTGCTGGTCCTGAGCA
  GAGGTGAGAGTGAATTGGACGCCAAGATCCCATCCACAGGGGATGCCACAGAATGGCGGA
  ATCCTCACCTGTCCATGCTGGGGTCCTGCCAGCCAGCCCCCTCCTGCCAGAAGTGCATCC
  TCTCACACCCCAGCTGTGCATGGTGCAAGCAACTGAACTTCACCGCGTCGGGAGAGGCGG
  AGGCGCGGCGCTGCGCCCGACGAGAGGAGCTGCTGGCTCGAGGCTGCCCGCTGGAGGAGC
  TGGAGGAGCCCCGCGGCCAGCAGGAGGTGCTGCAGGACCAGCCGCTCAGCCAGGGCGCCC
  GCGGAGAGGGTGCCACCCAGCTGGCGCCGCAGCGGGTCCGGGTCACGCTGCGGCCTGGGG
  AGCCCCAGCAGCTCCAGGTCCGCTTCCTTCGTGCTGAGGGATACCCGGTGGACCTGTACT
  ACCTTATGGACCTGAGCTACTCCATGAAGGACGACCTGNAACGCGTGCGCCAGCTCGGGC
  ACGCTCTGCTGGTCCGGCTGCANGAAGTCACCCATTCTGTGCGCATTGGGTTNTGGTTCC
  TTTGTGGGACAAACGGTGCTGNCCTTTGTGAGCACAGTACCCTTCAACTGCGCCACCCTG
  CCCANCCGGCTGAGCGCTGCCGTCACATTCAGTTTCCCATGTGCTGTCCCCTGACGGGGA
  CGCACAGCTTCAACGGGGAGGTGGGCCCCNAAATGTGTCCGCATCTGACTNCCCTGAANG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000889 unedited
  CGCGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTCTGAGGTAAGACTTTA
  TTGTATACTTGGGTGGGGTAGCCCAGATGGATGCAAGGTTGCAGGCATGGGAAGCAGCCC
  TCTTGGGTGTCACTCTGAAAATGAAGTAGGGTGGTGGCCGCACCTCGCCAGTGAATTAGT
  CCCCTACCAAGGTCTTACAGACCCACCCTTCCTCTCACCCTCCAGTTCCCACTGTCCTCC
  AAGGAGAAGAGCCTTGGGTAAGTGTCCCTCCCTCCTTCAGAGAGTGGGACTGTCTGCCTC
  TTGAAAGCGAGGATTGATGGTGGTCGTGATGGCACTTTTGTAGAGAGGATTACTGTCCTG
  CTTCCAGTTGAGTTGTTGCTGCTCCTTCTCAAAGCGACTGTATTCCCGGCGGTCATAGAT
  TTCCACCGAGAGCCGGTAAGCCAGGACCAGCCCCAGCCCCACTGCCACGATGCCCCCTAC
  GCAGCCCAGCACAATGGCCTGCGTGTGGTCTGCTCCCTTTTCTTGGGGTCTCACTCTGAG
  CACGACCGTGCCTCTGGCGTCATCCTCCACCAAGAAGAAGAACAGCTGGTTGTCCAGGGT
  CCGCTCTTTGCACCAGCCATCATCCAAGATAGGGGCCAAGGCCAGGGTCACATTGGTATG
  GGCACAAGCTGTACTGCATTTGTTGGCCAGTGGGCCAGTTCTTGAGGCCCCCACTCTGCA
  CAGTTCCCGTGTCTCTCGCATGGTGTTTTGCACCCTGCGCCTTGTTCGCATAAAGCACCA
  TATTACCCGTTCAAGCACTCGCAGGGGTTTGATTTGGCACGTCCTTGCCCACTGAAAGCC
  TCCCTCGGGACTGTGGCACCGTTCATGTCCCCCTTGATTCGCATGCTTTGCCCTGCGGTT
  GAATGAAAGGACATACTCACTTGGAGCGACCAAGCTCCGCAAGATGCCCTTTGTGTCAAT
  TGATATGTACACTGCCAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_000889
• Insert Size: 2500 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000889.1, NP_000880.1
• RefSeq Size: 2798 bp
• RefSeq ORF: 2397 bp
• Locus ID: 3695
• UniProt ID: P26010
• Cytogenetics: 12q13.13
• Domains: INB, PSI
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton
• Gene Summary: This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
  Transcript Variant: This variant (1) represents the longer transcript.