TNFRSF1B (NM_001066) Human Untagged Clone

CAT#: SC119459

TNFRSF1B (untagged)-Human tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TNFRSF1B
• Synonyms: CD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001066 edited
  GAATTCGGCACGAGGCGAGCGCAGCGGAGCCTGGAGAGAAGGCGCTGGGCTGCGAGGGCG
  CGAGGGCGCGAGGGCAGGGGGCAACCGGACCCCGCCCGCACCCATGGCGCCCGTCGCCGT
  CTGGGCCGCGCTGGCCGTCGGACTGGAGCTCTGGGCTGCGGCGCACGCCTTGCCCGCCCA
  GGTGGCATTTACACCCTACGCCCCGGAGCCCGGGAGCACATGCCGGCTCAGAGAATACTA
  TGACCAGACAGCTCAGATGTGCTGCAGCAAATGCTCGCCGGGCCAACATGCAAAAGTCTT
  CTGTACCAAGACCTCGGACACCGTGTGTGACTCCTGTGAGGACAGCACATACACCCAGCT
  CTGGAACTGGGTTCCCGAGTGCTTGAGCTGTGGCTCCCGCTGTAGCTCTGACCAGGTGGA
  AACTCAAGCCTGCACTCGGGAACAGAACCGCATCTGCACCTGCAGGCCCGGCTGGTACTG
  CGCGCTGAGCAAGCAGGAGGGGTGCCGGCTGTGCGCGCCGCTGCGCAAGTGCCGCCCGGG
  CTTCGGCGTGGCCAGACCAGGAACTGAAACATCAGACGTGGTGTGCAAGCCCTGTGCCCC
  GGGGACGTTCTCCAACACGACTTCATCCACGGATATTTGCAGGCCCCACCAGATCTGTAA
  CGTGGTGGCCATCCCTGGGAATGCAAGCATGGATGCAGTCTGCACGTCCACGTCCCCCAC
  CCGGAGTATGGCCCCAGGGGCAGTACACTTACCCCAGCCAGTGTCCACACGATCCCAACA
  CACGCAGCCAACTCCAGAACCCAGCACTGCTCCAAGCACCTCCTTCCTGCTCCCAATGGG
  CCCCAGCCCCCCAGCTGAAGGGAGCACTGGCGACTTCGCTCTTCCAGTTGGACTGATTGT
  GGGTGTGACAGCCTTGGGTCTACTAATAATAGGAGTGGTGAACTGTGTCATCATGACCCA
  GGTGAAAAAGAAGCCCTTGTGCCTGCAGAGAGAAGCCAAGGTGCCTCACTTGCCTGCCGA
  TAAGGCCCGGGGTACACAGGGCCCCGAGCAGCAGCACCTGCTGATCACAGCGCCGAGCTC
  CAGCAGCAGCTCCCTGGAGAGCTCGGCCAGTGCGTTGGACAGAAGGGCGCCCACTCGGAA
  CCAGCCACAGGCACCAGGCGTGGAGGCCAGTGGGGCCGGGGAGGCCCGGGCCAGCACCGG
  GAGCTCAGATTCTTCCCCTGGTGGCCATGGGACCCAGGTCAATGTCACCTGCATCGTGAA
  CGTCTGTAGCAGCTCTGACCACAGCTCACAGTGCTCCTCCCAAGCCAGCTCCACAATGGG
  AGACACAGATTCCAGCCCCTCGGAGTCCCCGAAGGACGAGCAGGTCCCCTTCTCCAAGGA
  GGAATGTGCCTTTCGGTCACAGCTGGAGACGCCAGAGACCCTGCTGGGGAGCACCGAAGA
  GAAGCCCCTGCCCCTTGGAGTGCCTGATGCTGGGATGAAGCCCAGTTAACCAGGCCGGTG
  TGGGCTGTGTCGTAGCCAAGGTGGGCTGAGCCCTGGCAGGATGACCCTGCGAAGGGGCCC
  TGGTCCTTCCAGGCCCCCACCACTAGGACTCTGAGGCTCTTTCTGGGCCAAGTTCCTCTA
  GTGCCCTCCACAGCCGCAGCCTCCCTCTGACCTGCAGGCCAAGAGCAGAGGCAGCGAGTT
  GGGGAAAGCCTCTGCTGCCATGGCGTGTCCCTCTCGGAAGGCTGGCTGGGCATGGACGTT
  CGGGGCATGCTGGGGCAAGTCCCTGACTCTCTGTGACCTGCCCCGCCCAGCTGCACCTGC
  CAGCCTGGCTTCTGGAGCCCTTGGGTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTC
  TCCCCCTGGGCTCTGCCCCAGCTCTGGCTTCCAGAAAACCCCAGCATCCTTTTCTGCAGA
  GGGGCTTTCTGGAGAGGAGGGATGCTGCCTGAGTCACCCATGAAGACAGGACAGTGCTTC
  AGCCTGAGGCTGAGACTGCGGGATGGTCCTGGGGCTCTGTGCAGGGAGGAGGTGGCAGCC
  CTGTAGGGAACGGGGTCCTTCAAGTTAGCTCAGGAGGCTTGGAAAGCATCACCTCAGGCC
  AGGTGCAGTGGCTCACGCCTATGATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGXXXXX
  XXXXXXXXCCAGCCTGGGCGACAGAGCGAGAGTCTGTCTCAAAAAAAAAAAAAAAAAACT
  CGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001066 unedited
  NNGGTTAAAATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGGCACGAGGCGAGCG
  CAGCGGAGCCTGGAGAGAAGGCGCTGGGCTGCGAGGGCGCGAGGGCGCGAGGGCAGGGGG
  CAACCGGACCCCGCCCGCACCCATGGCGCCCGTCGCCGTCTGGGCCGCGCTGGCCGTCGG
  ACTGGAGCTCTGGGCTGCGGCGCACGCCTTGCCCGCCCAGGTGGCATTTACACCCTACGC
  CCCGGAGCCCGGGAGCACATGCCGGCTCAGAGAATACTATGACCAGACAGCTCAGATGTG
  CTGCAGCAAATGCTCGCCGGGCCAACATGCAAAAGTCTTCTGTACCAAGACCTCGGACAC
  CGTGTGTGACTCCTGTGAGGACAGCACATACACCCAGCTCTGGAACTGGGTTCCCGAGTG
  CTTGAGCTGTGGCTCCCGCTGTAGCTCTGACCAGGTGGAAACTCAAGCCTGCACTCGGGA
  ACAGAACCGCATCTGCACCTGCAGGCCCGGCTGGTACTGCGCGCTGAGCAAGCAGGAGGG
  GTGCCGGCTGTGCGCGCCGCTGCGCAAGTGCCGCCCGGGCTTCGGCGTGGCCAGACCAGG
  AACTGAAACATCAGACGTGGTGTGCAAGCCCTGTGCCCCGGNGACGTTCTCCAACACGAC
  TTCATCCACGGATATTTGCAGGCCCCACCAGATCTGTAACGTGGTGGCCATCCCTGGGAA
  TGCAAGCATGGATGCAGTCTGCACGTCCACGTCCCCCACCGGNAGTATGGCCCCAGGGGC
  AGTACACTTACCCCAGCCAGTGTCCACACGATCCCAACACACGCAGCCAACTCCAGAACC
  CAGCACTGCTCCCAGCACCTNCTTCCTGCGTCCATGGGCCCCAGCCCCCAGCTGAAGGNA
  GCACT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001066 unedited
  TATGGACCGCGGGCCGCAATCTAGNGTCGAGTTTTTTTTTTTTTTTTTTGAGACAGACTC
  TCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCCCTGCAACCTCCGCT
  TCCCGGGTTCAAACGATTTCCCAGCCTCAGGCTTCTGAGTAGCTGGGACTATAGGTGCCC
  GCCACCACGCCCGGCTAATTTCTGTATTTTTAGTAGAGATGGGGTTTTACCATGTTGGCC
  AGGCTGGTCTCGAACTCCTAACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTG
  GGATCATAGGCGTGAGCCACTGCACCTGGCCTGAGGTGATGCTTTCCAAGCCTCCTGAGC
  TAACTTGAAGGACCCCGTTCCCTACAGGGCTGCCACCTCCTCCCTGCACAGAGCCCCAGG
  ACCATCCCGCAGTCTCAGCCTCAGGCTGAAGCACTGTCCTGTCTTCATGGGTGACTCAGG
  CAGCATCCCTCCTCTCCAGAAAGCCCCTCTGCAGAAAAGGATGCTGGGGTTTTCTGGAAG
  CCAGAGCTGGGGCAGAGCCCAGGGGGAGAAACAAACAAACAAACAAACAAACAAACAAAA
  AACCCAAGGGCTCCAGAAGCCAGGCTGGCAGGTGCAGCTGGGCGGGGCAGGTCACAGAGA
  GTCAGGGACTTGCCCCAGCATGCCCCCGACGTCCATGCCCAGCCAGCCTTTCGAGAGGGA
  CACGCCATGCCAGCAGAGGCTTTCCCCAACTCGCTGCCTCTGCTCTGGCCTGCAGTCAAA
  GGGAGCTGNNCGCTGTGAGCCACTANAGAACTTGGCCCAGAAGAGCCTANAGTCCTATGT
  GGGGGCCTGGAAGACAGGCCCCTTCCAGGTTCACCTGCCAGCCTCANCCACTTTGGTACC
  AAAGCCCAACCGCCTGGNTACTGGCTCATCCACATCAGCCTCCAGGGCAGGGCTTCTTCG
  GTCTCCCAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001066
• Insert Size: 2700 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001066.2, NP_001057.1
• RefSeq Size: 3682 bp
• RefSeq ORF: 1386 bp
• Locus ID: 7133
• UniProt ID: P20333
• Cytogenetics: 1p36.22
• Domains: TNFR
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Adipocytokine signaling pathway, Amyotrophic lateral sclerosis (ALS), Cytokine-cytokine receptor interaction
• Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]