alpha 1 Catenin (CTNNA1) (NM_001903) Human Untagged Clone

CAT#: SC118935

CTNNA1 (untagged)-Human catenin (cadherin-associated protein), alpha 1, 102kDa (CTNNA1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: alpha 1 Catenin
• Synonyms: CAP102; MDPT2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC118935 sequence for NM_001903 edited (data generated by NextGen Sequencing)
  ATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATC
  AGGACTCTGGCAGTTGAGAGACTGTTGGAGCCTCTTGTTACACAGGTTACAACCCTTGTA
  AACACCAATAGTAAAGGGCCCTCTAATAAGAAGAGAGGTCGTTCTAAGAAGGCCCATGTT
  TTGGCTGCATCTGTTGAACAAGCAACTGAGAATTTCTTGGAGAAGGGGGATAAAATTGCG
  AAGGAGAGCCAGTTTCTCAAGGAGGAGCTTGTGGCTGCTGTAGAAGATGTTCGAAAACAA
  GGTGATTTGATGAAGGCTGCTGCAGGAGAGTTCGCAGATGATCCCTGCTCTTCTGTGAAG
  CGAGGCAACATGGTTCGGGCAGCTCGAGCTTTGCTCTCTGCTGTTACCCGGTTGCTGATT
  TTGGCTGACATGGCAGATGTCTACAAATTACTTGTTCAGCTGAAAGTTGTGGAAGATGGT
  ATCTTGAAGTTGAGGAATGCTGGCAATGAACAAGACTTAGGAATCCAGTATAAAGCCCTA
  AAACCTGAAGTGGATAAGCTGAACATTATGGCAGCCAAAAGACAACAGGAATTGAAAGAT
  GTTGGCCATCGTGATCAGATGGCTGCAGCTAGAGGAATCCTGCAGAAGAACGTTCCGATC
  CTCTATACTGCATCCCAGGCATGCCTACAGCACCCTGATGTCGCAGCCTATAAGGCCAAC
  AGGGACCTGATATACAAGCAGCTGCAGCAGGCGGTCACAGGCATTTCCAATGCAGCCCAG
  GCCACTGCCTCAGACGATGCCTCACAGCACCAGGGTGGAGGAGGAGGAGAACTGGCATAT
  GCACTCAATAACTTTGACAAACAAATCATTGTGGACCCCTTGAGCTTCAGCGAGGAGCGC
  TTTAGGCCTTCCCTGGAGGAGCGTCTGGAAAGCATCATTAGTGGGGCTGCCTTGATGGCC
  GACTCGTCCTGCACGCGTGATGACCGTCGTGAGCGAATTGTGGCAGAGTGTAATGCTGTC
  CGCCAGGCCCTGCAGGACCTGCTTTCGGAGTACATGGGCAATGCTGGACGTAAAGAAAGA
  AGTGATGCACTCAATTCTGCAATAGATAAAATGACCAAGAAGACCAGGGACTTGCGTAGA
  CAGCTCCGCAAAGCTGTCATGGACCACGTTTCAGATTCTTTCCTGGAAACCAATGTTCCA
  CTTTTGGTATTGATTGAAGCTGCAAAGAATGGAAATGAGAAAGAAGTTAAGGAGTATGCC
  CAAGTTTTCCGTGAACATGCCAACAAATTGATTGAGGTTGCCAACTTGGCCTGTTCCATC
  TCAAATAATGAAGAAGGTGTAAAGCTTGTTCGAATGTCTGCAAGCCAGTTAGAAGCCCTC
  TGTCCTCAGGTTATTAATGCTGCACTGGCTTTAGCAGCAAAACCACAGAGTAAACTGGCC
  CAAGAGAACATGGATCTTTTTAAAGAACAATGGGAAAAACAAGTCCGTGTTCTCACAGAT
  GCTGTCGATGACATTACTTCCATTGATGACTTCTTGGCTGTCTCAGAGAATCACATTTTG
  GAAGATGTGAACAAATGTGTCATTGCTCTCCAAGAGAAGGATGTGGATGGCCTGGACCGC
  ACAGCTGGTGCAATTCGAGGCCGGGCAGCCCGGGTCATTCACGTAGTCACCTCAGAGATG
  GACAACTATGAGCCAGGAGTCTACACAGAGAAGGTTCTGGAAGCCACTAAGCTGCTCTCC
  AACACAGTCATGCCACGTTTTACTGAGCAAGTAGAAGCAGCCGTGGAAGCCCTCAGCTCG
  GACCCTGCCCAGCCCATGGATGAGAATGAGTTTATCGATGCTTCCCGCCTGGTATATGAT
  GGCATCCGGGACATCAGGAAAGCAGTGCTGATGATAAGGACCCCTGAGGAGTTGGATGAC
  TCTGACTTTGAGACAGAAGATTTTGATGTCAGAAGCAGGACGAGCGTCCAGACAGAAGAC
  GATCAGCTGATAGCTGGCCAGAGTGCCCGGGCGATCATGGCTCAGCTTCCCCAGGAGCAA
  AAAGCGAAGATTGCGGAACAGGTGGCCAGCTTCCAGGAAGAAAAGAGCAAGCTGGATGCT
  GAAGTGTCCAAATGGGACGACAGTGGCAATGACATCATTGTGCTGGCCAAGCAGATGTGC
  ATGATTATGATGGAGATGACAGACTTTACCCGAGGTAAAGGACCACTCAAAAATACATCG
  GATGTCATCAGTGCTGCCAAGAAAATTGCTGAGGCAGGATCCAGGATGGACAAGCTTGGC
  CGCACCATTGCAGACCATTGCCCCGACTCGGCTTGCAAGCAGGACCTGCTGGCCTACCTG
  CAACGCATCGCCCTCTACTGCCACCAGCTGAACATCTGCAGCAAGGTCAAGGCCGAGGTG
  CAGAATCTCGGCGGGGAGCTTGTTGTCTCTGGGGTGGACAGCGCCATGTCCCTGATCCAG
  GCAGCCAAGAACTTGATGAATGCTGTGGTGCAGACAGTGAAGGCATCCTACGTCGCCTCT
  ACCAAATACCAAAAGTCACAGGGTATGGCTTCCCTCAACCTTCCTGCTGTGTCATGGAAG
  ATGAAGGCACCAGAGAAAAAGCCATTGGTGAAGAGAGAGAAACAGGATGAGACACAGACC
  AAGATTAAACGGGCATCTCAGAAGAAGCACGTGAACCCGGTGCAGGCCCTCAGCGAGTTC
  AAAGCTATGGACAGCATCTAA
  
  Clone variation with respect to NM_001903.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001903 unedited
  TTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCCTCGTGCCGAATT
  CGGCACGAGGCCGGACTGGAGGGAGACAAAGCAGCGCCCGTCTGCTTCGGGCCTCTGGAA
  TTTAGCGCTCGCCCAGCTAGCCGCAGAAATGACTGCTGTCCATGCAGGCAACATAAACTT
  CAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGGAGCC
  TCTTGTTACACAGGTTACAACCCTTGTAAACACCAATAGTAAAGGGCCCTCTAATAAGAA
  GAGAGGTCGTTCTAAGAAGGCCCATGTTTTGGCTGCATCTGTTGAACAAGCAACTGAGAA
  TTTCTTGGAGAAGGGGGATAAAATTGCGAAGGAGAGCCAGTTTCTCAAGGAGGAGCTTGT
  GGCTGCTGTAGAAGATGTTCGAAAACAAGGTGATTTGATGAAGGCTGCTGCAGGAGAGTT
  CGCAGATGATCCCTGCTCTTCTGTGAAGCGAGGCAACATGGTTCGGGCAGCTCGAGCTTT
  GCTCTCTGCTGTTACCCGGTTGCTGATTTTGGCTGACATGGCAGATGTCTACAAATTACT
  TGTTCAGCTGAAAGTTGTGGAAGATGGTATCTTGAAGTTGAGGAATGCTGGCAATGAACA
  AGACTTANGAATCCAGTATAAAGCCCTAAAACCTGAAGTGGATAAGCTGAACATTATGGC
  AGCCAAAAGACAACAGGAATTGAAAGATGTTGGCCATCGTGATCAGATGGCTGCAGCTAG
  AGGAATCCTGCAGAAAGACGNTNNCGATCCTCTATACTGCATCCCCAGCATGCCTACAGC
  ACCCTGGATGTCGCAGCCTATAAGGCCCACAGGGACCTGATATANCAGCAGCTGCAGCAA
  GGCGGTCACG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001903 unedited
  TAAAAGACAACTTTCATTAATGGTCCTGCAGCAGCGTACATTAGTAATTATAACAATGCA
  TTAAAATTTTCATTTCATGTCATAGAGAATCAGTTTTCTTCATGATACATTATGTTTTAC
  TGAGTGAGTTTGTCCCTCCAGAGACCTTTCTGGGAACATGCCTTCTCCAGGGACTGCTTC
  CTAAGATGCCCAGGTTGCTTACCACAGGTCATCTTTGGTCATTTAAAAGCAGTCAAGCTG
  TCTGGACTGCACCCTCTCAACTGAAGTTGAGCCAAATTCCCTTCTCTCAAACCCTAACGC
  CGCCATCACTAAGAGAATGGGCATCTCGGCTTGGTCAGAGCATTACTAACAAGCTAATGT
  GGGATTCTCTTTGGTTATGAATTTTTATTTTTATTTAAGCATACAAAAAATACAGCTAGA
  AGTAGGCTCCTGCATTCTAAAAGCATTTTTAATCAACTTAAACTATGTTCTTGGAAAATT
  CACCACCTGGACTGGTTCAGTCTGCCCATTTCCCTGTGGAATCTAGTATCAGTGTTGTAT
  TTAGCAAATTCATTTGAGTGACGAACAGTGACTGATATTCAGGAGCCCCGAGGGGTGGGG
  GCGGCCGGCCTGGGCAGACTTAGATGCTGTCCATAGCTTTGAACTCGCTGAGGGCCTGCA
  CCGGGTTCACGTGCTTCTTCTGAGATGCCCGTTTAATCTTGGGCTGTGTCTCATCCTGTT
  TCTCTCTCTTCACCAATGGCTTTTTCTCTGGTGCCTTCATCTTCCATGACACAGCAGGAA
  AGTTGAGGGNAAGCCATACCCTGTGACTTTNGGNTATTGGGTANAAGCGACGTAGGATGC
  CTTCACTGTCTGGACCACAGCATCATCAAATTCTGGGCTGCTGGATAGGGACATGGCGCT
  GTTCACCCCAGAACAACAGCTTCCCGCCGGATTTGGCCCTNGCCTTGCACTTTTGNAAAT
  GTAACCTGGGGCATAAAGGGAATGCCTTAAGGTAGGCAACAGCCTCTTTTCACCGATACG
  GAAGGTGTCAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001903
• Insert Size: 3670 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001903.2, NP_001894.2
• RefSeq Size: 3778 bp
• RefSeq ORF: 2721 bp
• Locus ID: 1495
• UniProt ID: P35221
• Cytogenetics: 5q31.2
• Domains: Vinculin
• Protein Families: Druggable Genome
• Protein Pathways: Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Endometrial cancer, Leukocyte transendothelial migration, Pathways in cancer, Tight junction
• Gene Summary: This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016]