TrkC (NTRK3) (NM_002530) Human Untagged Clone

CAT#: SC118578

NTRK3 (untagged)-Human neurotrophic tyrosine kinase, receptor, type 3 (NTRK3), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TrkC
• Synonyms: gp145(trkC); GP145-TrkC; TRKC
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_002530 edited
  ATGGATGTCTCTCTTTGCCCAGCCAAGTGTAGTTTCTGGCGGATTTTCTTGCTGGGAAGC
  GTCTGGCTGGACTATGTGGGCTCCGTGCTGGCTTGCCCTGCAAATTGTGTCTGCAGCAAG
  ACTGAGATCAATTGCCGGCGGCCGGACGATGGGAACCTCTTCCCCCTCCTGGAAGGGCAG
  GATTCAGGGAACAGCAATGGGAACGCCAGTATCAACATCACGGACATCTCAAGGAATATC
  ACTTCCATACACATAGAGAACTGGCGCAGTCTTCACACGCTCAACGCCGTGGACATGGAG
  CTCTACACCGGACTTCAAAAGCTGACCATCAAGAACTCAGGACTTCGGAGCATTCAGCCC
  AGAGCCTTTGCCAAGAACCCCCATTTGCGTTATATAAACCTGTCAAGTAACCGGCTCACC
  ACACTCTCGTGGCAGCTCTTCCAGACGCTGAGTCTTCGGGAATTGCAGTTGGAGCAGAAC
  TTTTTCAACTGCAGCTGTGACATCCGCTGGATGCAGCTCTGGCAGGAGCAGGGGGAGGCC
  AAGCTCAACAGCCAGAACCTCTACTGCATCAACGCTGATGGCTCCCAGCTTCCTCTCTTC
  CGCATGAACATCAGTCAGTGTGACCTTCCTGAGATCAGCGTGAGCCACGTCAACCTGACC
  GTACGAGAGGGTGACAATGCTGTTATCACTTGCAATGGCTCTGGATCACCCCTTCCTGAT
  GTGGACTGGATAGTCACTGGGCTGCAGTCCATCAACACTCACCAGACCAATCTGAACTGG
  ACCAATGTTCATGCCATCAACTTGACGCTGGTGAATGTGACGAGTGAGGACAATGGCTTC
  ACCCTGACGTGCATTGCAGAGAACGTGGTGGGCATGAGCAATGCCAGTGTTGCCCTCACT
  GTCTACTATCCCCCACGTGTGGTGAGCCTGGAGGAGCCTGAGCTGCGCCTGGAGCACTGC
  ATCGAGTTTGTGGTGCGTGGCAACCCCCCACCAACGCTGCACTGGCTGCACAATGGGCAG
  CCTCTGCGGGAGTCCAAGATCATCCATGTGGAATACTACCAAGAGGGAGAGATTTCCGAG
  GGCTGCCTGCTCTTCAACAAGCCCACCCACTACAACAATGGCAACTATACCCTCATTGCC
  AAAAACCCACTGGGCACAGCCAACCAGACCATCAATGGCCACTTCCTCAAGGAGCCCTTT
  CCAGAGAGCACGGATAACTTTATCTTGTTTGACGAAGTGAGTCCCACACCTCCTATCACT
  GTGACCCACAAACCAGAAGAAGACACTTTTGGGGTATCCATAGCAGTTGGACTTGCTGCT
  TTTGCCTGTGTCCTGTTGGTGGTTCTCTTCGTCATGATCAACAAATATGGTCGACGGTCC
  AAATTTGGAATGAAGGGTCCCGTGGCTGTCATCAGTGGTGAGGAGGACTCAGCCAGCCCA
  CTGCACCACATCAACCACGGCATCACCACGCCCTCGTCACTGGATGCCGGGCCCGACACT
  GTGGTCATTGGCATGACTCGCATCCCTGTCATTGAGAACCCCCAGTACTTCCGTCAGGGA
  CACAACTGCCACAAGCCGGACACGTATGTGCAGCACATTAAGAGGAGAGACATCGTGCTG
  AAGCGAGAACTGGGTGAGGGAGCCTTTGGAAAGGTCTTCCTGGCCGAGTGCTACAACCTC
  AGCCCGACCAAGGACAAGATGCTTGTGGCTGTGAAGGCCCTGAAGGATCCCACCCTGGCT
  GCCCGGAAGGATTTCCAGAGGGAGGCCGAGCTGCTCACCAACCTGCAGCATGAGCACATT
  GTCAAGTTCTATGGAGTGTGCGGCGATGGGGACCCCCTCATCATGGTCTTTGAATACATG
  AAGCATGGAGACCTGAATAAGTTCCTCAGGGCCCATGGGCCAGATGCAATGATCCTTGTG
  GATGGACAGCCACGCCAGGCCAAGGGTGAGCTGGGGCTCTCCCAAATGCTCCACATTGCC
  AGTCAGATCGCCTCGGGTATGGTGTACCTGGCCTCCCAGCACTTTGTGCACCGAGACCTG
  GCCACCAGGAACTGCCTGGTTGGAGCGAATCTGCTAGTGAAGATTGGGGACTTCGGCATG
  TCCAGAGATGTCTACAGCACGGATTATTACAGGGTGGGAGGACACACCATGCTCCCCATT
  CGCTGGATGCCTCCTGAAAGCATCATGTACCGGAAGTTCACTACAGAGAGTGATGTATGG
  AGCTTCGGGGTGATCCTCTGGGAGATCTTCACCTATGGAAAGCAGCCATGGTTCCAACTC
  TCAAACACGGAGGTCATTGAGTGCATTACCCAAGGTCGTGTTTTGGAGCGGCCCCGAGTC
  TGCCCCAAAGAGGTGTACGATGTCATGCTGGGGTGCTGGCAGAGGGAACCACAGCAGCGG
  TTGAACATCAAGGAGATCTACAAAATCCTCCATGCTTTGGGGAAGGCCACCCCAATCTAC
  CTGGACATTCTTGGCTAG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002530 unedited
  CTGTTCACGATGTTGAAAACTCGNACTNCACTNTGAGGGNCGGACCGCCNAATCGGCACG
  AGGCTCCTCTTTTTTAGAAGCAGCGATCGGAGAGGATGTCTCTCTTTGCCCAGCCAAGTG
  TAGTTTCTGGCGGATTTTCTTGCTGGGAAGCGTCTGGCTGGACTATGTGGGCTCCGTGCT
  GGCTTGCCCTGCAAATTGTGTCTGCAGCAAGACTGAGATCAATTGCCGGCGGCCGGACGA
  TGGGAACCTCTTCCCCCTCCTGGAAGGGCAGGATTCAGGGAACAGCAATGGGAACGCCAG
  TATCAACATCACGGACATCTCAAGGAATATCACTTCCATACACATAGAGAACTGGCGCAG
  TCTTCACACGCTCAACGCCGTGGACATGGAGCTCTACACCGGACTTCAAAAGCTGACCAT
  CAAGAACTCAGGACTTCGGAGCATTCAGCCCAGAGCCTTTGCCAAGAACCCCCATTTGCG
  TTATATAAACCTGTCAAGTAACCGGCTCACCACACTCTCGTGGCAGCTCTTCCAGACGCT
  GAGTCTTCGGGAATTGCAGTTGGAGCAGAACTTTTTCAACTGCAGCTGTGACATCCGCTG
  GATGCAGCTCTGGCAGGAGCAGGGGGAGGCCAAGCTCAACAGCCAGAACCTCTACTGCAT
  CAACGCTGATGGCTCCCAGCTTCCTCTCTTCCGCATGAACATCAGTCAGTGTGACCTTCC
  TGAGATCAGCGTGAGCCACGTTAACCTGACCGTACGAGAGGGTGACCATGCTGTTATCAC
  TTGCAATGGCTCCTGGACCACCCCTTCCTGATGTGGACTGAATAGTTACTGGGCTGCAGT
  CCATTCACACTCACCAGGACAATCTGAAACTGGACCATGTTCATGCCCATCAACTGACGC
  TTGTGCATGTGACCAGTGAAGACACTGCCTTCACCTGT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002530 unedited
  CTTTCCAGGGCCAGGNATAGCACTGGGGAGGGGTCACAGGNATGCCACCCGGGATCTGTT
  CAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCA
  GTGTTGTATGTGTAGCAGGCACTTGAGTTTATATGAAGATGTTCGCTTCAGTCAAGGATG
  GAAGGAGTTGTGAGGTGGAAGGGAGATGTGAGGCAGGGAGAGAGGAGGCAACAGAGTATG
  AATTCATGACCACCAGCCACCACTAGCCAAGAATGTCCAGGTAGATTGGGGTGGCCTTCC
  CCAAAGCATGGAGGATTTTGTAGATCTCCTTGATGTTCAACCGCTGCTGTGGTTCCCTCT
  GCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAA
  CACGACCTTGGGTAATGCACTCAATGACCTCCGTGTTTGAGAGTTGGAACCATGGCTGCT
  TTCCATAGGTGAAGATCTCCCAGAGGATCACCCCGAAGCTCCATACATCACTCTCTGTAG
  TGAACTTCCGGTACATGATGCTTTCAGGAGGCATCCAGCGAATGGGGAGCATGGTGTGTC
  CTCCCACCCTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCT
  TCACTAGCAGATTCGCTCCAACCAGGCAGTTCCTGGTGGCCCAGTCTCGGTGCACAAAGT
  GCTGGGAGGCCAGGTACACCATACCCGNAGCGATCTGACTGGNCATGTGGAGCATTTGGG
  AGAGCCCCAGCTCACCCTTGGCCTGCGGTGGCTGTCCATCCACAAGATCATTGCATCTGG
  CCATGGGCCCTGANNGACTTATCANGTCTCATGCTTCATGANCAAGACATGAGAGAGGGG
  GCCCCATCGCCNCACTCATAGACTTGCATGGCTATGCTNCAGTTGGGAGCACTCGGCTCT
  TTGAATCTTCGCACCGGGGTGAATCT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002530
• Insert Size: 2800 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002530.2, NP_002521.2
• RefSeq Size: 2818 bp
• RefSeq ORF: 2478 bp
• Locus ID: 4916
• UniProt ID: Q16288
• Cytogenetics: 15q25.3
• Domains: LRRNT, LRRCT, pkinase, TyrKc, LRR, S_TKc, ig, IG
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Neurotrophin signaling pathway
• Gene Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
  Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.