KCNIP1 (NM_014592) Human Untagged Clone

CAT#: SC114946

KCNIP1 (untagged)-Human Kv channel interacting protein 1 (KCNIP1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KCNIP1
• Synonyms: KCHIP1; VABP
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC114946 sequence for NM_014592 edited (data generated by NextGen Sequencing)
  ATGGGGGCCGTCATGGGCACCTTCTCATCTCTGCAAACCAAACAAAGGCGACCCTCGAAA
  GATAAGATTGAAGATGAGCTGGAGATGACCATGGTTTGCCATCGGCCCGAGGGACTGGAG
  CAGCTCGAGGCCCAGACCAACTTCACCAAGAGGGAGCTGCAGGTCCTTTATCGAGGCTTC
  AAAAATGAGTGCCCCAGTGGTGTGGTCAACGAAGACACATTCAAGCAGATCTATGCTCAG
  TTTTTCCCTCATGGAGATGCCAGCACGTATGCCCATTACCTCTTCAATGCCTTCGACACC
  ACTCAGACAGGCTCCGTGAAGTTCGAGGACTTTGTAACCGCTCTGTCGATTTTATTGAGA
  GGAACTGTCCACGAGAAACTAAGGTGGACATTTAATTTGTATGACATCAACAAGGACGGA
  TACATAAACAAAGAGGAGATGATGGACATTGTCAAAGCCATCTATGACATGATGGGGAAA
  TACACATATCCTGTGCTCAAAGAGGACACTCCAAGGCAGCATGTGGACGTCTTCTTCCAG
  AAAATGGACAAAAATAAAGATGGCATCGTAACTTTAGATGAATTTCTTGAATCATGTCAG
  GAGGACGACAACATCATGAGGTCTCTCCAGCTGTTTCAAAATGTCATGTAA
  
  Clone variation with respect to NM_014592.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014592 unedited
  GGTTCACATTTTGTAATACGACTTCACTATAGGGCGGCCGCGAATCGGCACGAGGCCTCG
  TGCCGAATTCGGCACGAGGTAGCCTCGCCTCCACGCTTGCTGAATACCAAGCTGCAGGCG
  AGCTGCCGGGCGCTTTTCTCTCCTCCAATTCAGAGTAGACAAACCACGGGGATTTCTTTC
  CAGGGTAGGGGAGGGGCCGGGCCCGGGGTCCCAACTCGCACTCAAGTCTTCGCTGCCATG
  GGGGCCGTCATGGGCACCTTCTCATCTCTGCAAACCAAACAAAGGCGACCCTCGAAAGAT
  AAGATTGAAGATGAGCTGGAGATGACCATGGTTTGCCATCGGCCCGAGGGACTGGAGCAG
  CTCGAGGCCCAGACCAACTTCACCAAGAGGGAGCTGCAGGTCCTTTATCGAGGCTTCAAA
  AATGAGTGCCCCAGTGGTGTGGTCAACGAAGACACATTCAAGCAGATCTATGCTCAGTTT
  TTCCCTCATGGAGATGCCAGCACGTATGCCCATTACCTCTTCAATGCCTTCGACACCACT
  CAGACAGGCTCCGTGAAGTTCGAGGACTTTGTAACCGCTCTGTCGATTTTATTGAGAGGA
  ACTGTCCACGAGAAACTAAGGTGGACATTTAATTTGTATGACATCAACAAGGACGGATAC
  ATAAACAAAGAGGAGATGATGGACATTGTCAAAGCCATCTATGACATGATGGGGAAATAC
  ACATATCCTGTGCTCAAAGAGGACACTCCAAGGCAGCATGTGGACGTCTTCTTCCAGAAA
  TGGACAAAAATAAGATGGCATCGTAACTTTAGATGAATTTCTTTGATCATGTCAGGAGGA
  CAACCACATCACTGAGTCTCTCCACCTGTTTCAAATGTCATGTAACTGTTGACACTCAGG
  CATTCAGCTCTCAAAAACATTGGACTAAACAACCN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_014592 unedited
  CCCAAATGTTGNACCGCGGCTCGCAANCTACGGAGCGGTTTTTTTTTTTTTTTTTTGAGG
  ATGTAAGAAATAGTTCTGTTTATTGGTTAGAACATGGTATAAAATTACAGCAATTTGCAG
  GCATTCTGGACTTCTTGGGAGGGACATGCAGCGCTGGGCTCAAGCAGGGGATGTGGTGGA
  GATATGGACCACTGGGCAATGGCTCCCTTCCTGGACATATTAAAGGACTTGTACTACCAG
  CACAAATGCCAGTGTGAGAGAATTATTGGTCCTCGTTTCTGGAAACAAATGACATGGGCA
  GTTTGGGTCATCAGACAATATCATGCTTAATAATTCAGTCCTATCCCACATATGTTAGGT
  GCTGGCTCTCCCAATCTGGTCATGACAGATCCTAATTGTTCTGGATAACTCTCATTCTTC
  CCACCAAAGGAAGAGAAACAGGCACATTGGTTTGGGAGGCCATCAGAGATGGTGTGCATC
  TGGCTCAGGTCCTCTTGCTTCCAGATTCACCAAGGTCTGCCTGACTTGGAGGCAGTGGGC
  TGGGGGCACGTAAGCAGCATATTTTGTGCACTACTGTTTAAGCTTAAGCAGAGGGACCTT
  CCATAGGGCAGCAGTGTGAGGAGATGAGCATGCTTCCAAAACAAACTCAAATTTCATCTT
  GTCTCTCTCAAGAAGAAGAAAGAGGAAGAGTTGGCAATCAGAGACTGAGCCACATGATGC
  TGGGTTCCATAGAAAGTCTTTAGCAGAGAATTCTTTCTAAGTGTAAAAGGTGTTTCTGTC
  CTAGATTTGGTGTGTAAAAACACAACAGGGCCGATCACGGTGTTAAGGTGGTTGTTTAGT
  ACAAGGCCCTTGAAAACTGAATGGCTGATGCTCCCCATTACATGACATTTGAAAACGCTG
  GAGAGACCTCCGAAGGTTGCCCCCCTTCGC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_014592
• Insert Size: 1730 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_014592.2, NP_055407.1
• RefSeq Size: 2020 bp
• RefSeq ORF: 651 bp
• Locus ID: 30820
• UniProt ID: Q9NZI2
• Cytogenetics: 5q35.1
• Domains: EFh
• Protein Families: Druggable Genome, Ion Channels: Other
• Gene Summary: This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
  Transcript Variant: This variant (2, also known as KCNP1-Ib deltaII) uses an alternate in-frame splice site in the 5' coding region compared to variant 5. It encodes isoform 2 which is shorter than isoform 5.