CCR10 (NM_016602) Human Untagged Clone

CAT#: SC114153

CCR10 (untagged)-Human chemokine (C-C motif) receptor 10 (CCR10)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CCR10
• Synonyms: GPR2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC114153 sequence for NM_016602 edited (data generated by NextGen Sequencing)
  ATGGGGACGGAGGCCACAGAGCAGGTTTCCTGGGGCCATTACTCTGGGGATGAAGAGGAC
  GCATACTCGGCTGAGCCACTGCCGGAGCTTTGCTACAAGGCCGATGTCCAGGCCTTCAGC
  CGGGCCTTCCAACCCAGTGTCTCCCTGACCGTGGCTGCGCTGGGTCTGGCCGGCAATGGC
  CTGGTCCTGGCCACCCACCTGGCAGCCCGACGCGCAGCGCGCTCGCCCACCTCTGCCCAC
  CTGCTCCAGCTGGCCCTGGCCGACCTCTTGCTGGCCCTGACTCTGCCCTTCGCGGCAGCA
  GGGGCTCTTCAGGGCTGGAGTCTGGGAAGTGCCACCTGCCGCACCATCTCTGGCCTCTAC
  TCGGCCTCCTTCCACGCCGGCTTCCTCTTCCTGGCCTGTATCAGCGCCGACCGCTACGTG
  GCCATCGCGCGAGCGCTCCCAGCCGGGCCGCGGCCCTCCACTCCCGGCCGCGCACACTTG
  GTCTCCGTCATCGTGTGGCTGCTGTCACTGCTCCTGGCGCTGCCTGCGCTGCTCTTCAGC
  CAGGATGGGCAGCGGGAAGGCCAACGACGCTGTCGCCTCATCTTCCCCGAGGGCCTCACG
  CAGACGGTGAAGGGGGCGAGCGCCGTGGCGCAGGTGGCCCTGGGCTTCGCGCTGCCGCTG
  GGCGTCATGGTAGCCTGCTACGCGCTTCTGGGCCGTACGCTGCTGGCCGCCAGGGGGCCC
  GAGCGCCGGCGTGCGCTGCGCGTCGTGGTGGCTCTGGTGGCGGCCTTCGTGGTGCTGCAG
  CTGCCCTACAGCCTCGCCCTGCTGCTGGATACTGCCGATCTACTGGCTGCGCGCGAGCGG
  AGCTGCCCTGCCAGCAAACGCAAGGATGTCGCACTGCTGGTGACCAGCGGCTTGGCCCTC
  GCCCGCTGTGGCCTCAATCCCGTTCTCTACGCCTTCCTGGGCCTGCGCTTCCGCCAGGAC
  CTGCGGAGGCTGCTACGGGGTGGGAGCTGCCCCTCAGGGCCTCAACCCCGCCGCGGCTGC
  CCCCGCCGGCCCCGCCTTTCTTCCTGCTCAGCTCCCACGGAGACCCACAGTCTCTCCTGG
  GACAACTAG
  
  Clone variation with respect to NM_016602.2
  696 c=>t
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_016602 unedited
  GGCCTACGGGTACGCGGCCGCCTGGTGGTGGNTAACAACACATTCGCCCTTATGTGGCAA
  GGCACAGAGGTAGTCCCTTTAGGTCCCTGCCTCTTTCTCAGTGTTCCCCCACCTACTCCC
  CTTTCCCACGACCCTCAGCCTGCCCCCTCCTCTAGATTCGCAGCCCTAGTTGTCCCAGGA
  GAGACTGTGGGTCTCCGTGGGAGCTGAGCATGATTTTTGGCGGGGCCGGCGGGGGCAGCC
  GCGGCGGGGTTGAGGCCCTGAGGGGCAGCTCCCACCCCGTAGCAGCCTCCGCAGGTCCTG
  GCGGAAGCGCAGGCCCAGGAAGGCGTAGAGAACGGGATTGAGGCCACAGCGGGCGAGGGC
  CAAGCCGCTGGTCACCAGCAGTGCGACATCCTTGCGTTTGCTGGCAGGGCAGCTCCGCTC
  GCGCGCAGCCAGTAGATCGGCAGTATCCAGCAGCAGGGCGAGGCTGTAGGGCAGCTGCAG
  CACCACGAAGGCCGCCACCAGAGCCACCACGACGCGCAGCGCACGCCGGCGCTCGGGCCC
  CCTGGCGGCCAGCAGCGTACGGCCCAGAAGCGCGTAGCAGGCTACCATGACGCCCAGCGG
  CAGCGCGAAGCCCAGGGCCACCTGCGCCACGGCGCTCGCCCCCTTCACCGTCTGCGTGAG
  GCCCTCGGGGAAGATGATGCGACAGCGTCGTTGGCCTTCCCGCTGCCCATCCTGGCTGAA
  GAGCAGCGCATGCAGCGCCCGGGAGCAGTGACAGCAGCCACACGATGACGGAGACCAAAT
  GTGCGCGGCCCGGAGTGGAGGGCCCCGGCCCGGCTGGGAGCGCTCGCGCGATGGCCACTT
  AACGGTCGGGGCTGTTACAGGCCAGGAAGAGAA
  
• Restriction Sites: Please inquire
• ACCN: NM_016602
• Insert Size: 1300 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_016602.1, NP_057686.1
• RefSeq Size: 1244 bp
• RefSeq ORF: 1089 bp
• Locus ID: 2826
• UniProt ID: P46092
• Cytogenetics: 17q21.2
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction
• Gene Summary: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]