TBLR1 (TBL1XR1) (NM_024665) Human Untagged Clone

CAT#: SC112104

TBL1XR1 (untagged)-Human transducin (beta)-like 1 X-linked receptor 1 (TBL1XR1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TBLR1
• Synonyms: C21; DC42; IRA1; MRD41; TBLR1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC112104 sequence for NM_024665 edited (data generated by NextGen Sequencing)
  ATGAGTATAAGCAGTGATGAGGTCAACTTCTTGGTATATAGATACTTGCAAGAGTCAGGA
  TTTTCTCATTCAGCATTTACCTTTGGTATAGAAAGCCATATCAGTCAGTCCAATATAAAT
  GGTGCCCTCGTCCCACCCGCTGCATTGATTTCTATCATCCAGAAAGGTCTACAGTATGTA
  GAAGCAGAAGTTAGTATTAATGAGGATGGTACCTTGTTTGATGGTCGACCAATAGAGTCT
  CTGTCCCTGATAGATGCCGTAATGCCTGATGTAGTACAAACAAGACAACAAGCTTATAGA
  GATAAGCTTGCACAGCAACAGGCAGCAGCTGCTGCAGCTGCCGCAGCTGCAGCCAGCCAA
  CAAGGATCTGCAAAAAATGGAGAAAACACAGCAAATGGGGAGGAGAATGGAGCACATACT
  ATAGCAAATAATCATACTGATATGATGGAAGTGGATGGGGATGTTGAAATCCCTCCTAAT
  AAAGCTGTTGTGTTGCGGGGCCATGAATCTGAAGTTTTTATCTGTGCCTGGAACCCTGTT
  AGTGATCTCCTAGCATCAGGGTCTGGAGACTCAACAGCAAGAATATGGAATCTTAGTGAG
  AACAGCACCAGTGGCTCTACACAGTTAGTACTTAGACATTGTATACGAGAAGGAGGGCAA
  GATGTTCCAAGCAACAAGGATGTCACATCTCTAGATTGGAATAGTGAAGGTACACTTCTA
  GCAACTGGTTCCTATGATGGGTTTGCCAGAATATGGACTAAAGATGGTAACCTTGCTAGC
  ACCTTAGGGCAGCATAAAGGCCCTATATTTGCATTAAAATGGAATAAGAAAGGAAATTTC
  ATCCTAAGTGCTGGAGTAGACAAGACTACAATTATTTGGGACGCACATACTGGTGAAGCC
  AAGCAACAGTTTCCTTTTCATTCAGCACCAGCATTGGATGTTGATTGGCAGAGCAACAAC
  ACCTTTGCTTCTTGTAGTACAGATATGTGCATTCATGTCTGTAAATTAGGACAAGACAGA
  CCTATTAAAACATTCCAAGGACATACGAATGAAGTAAATGCTATCAAATGGGACCCAACT
  GGCAATCTCTTGGCCTCCTGTTCTGACGACATGACTTTAAAGATATGGAGTATGAAACAA
  GACAATTGTGTCCATGATTTGCAAGCACATAATAAAGAAATTTATACTATCAAATGGAGT
  CCAACAGGACCAGGGACTAATAATCCAAATGCCAACCTTATGTTAGCAAGTGCATCCTTT
  GATTCTACTGTTAGGTTATGGGATGTAGACCGAGGGATATGCATCCATACCTTGACAAAA
  CACCAAGAGCCTGTGTRCAGTGTAGCTTTCAGTCCTGATGGCAGGTATCTGGCAAGTGGT
  TCTTTTGACAAATGTGTACACATCTGGAACACGCAGACAGGTGCTCTAGTTCACAGCTAT
  AGGGGAACAGGTGGAATATTTGAAGTTTGCTGGAATGCAGCAGGAGACAAAGTTGGAGCC
  AGTGCATCAGATGGTTCAGTTTGTGTATTAGACCTTCGGAAATAG
  
  Clone variation with respect to NM_024665.4
  1337 a=>r
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_024665 unedited
  TTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGACCGGATATTCAGT
  TGCACATCCCCACATCAATGCACTGCCAATGGGTTATATCCTGTGTTGTGACCTCATGGT
  TTAAGTGGGAATAAAGATGAGTATAAGCAGTGATGAGGTCAACTTCTTGGTATATAGATA
  CTTGCAAGAGTCAGGATTTTCTCATTCAGCATTTACCTTTGGTATAGAAAGCCATATCAG
  TCAGTCCAATATAAATGGTGCCCTCGTCCCACCCGCTGCATTGATTTCTATCATCCAGAA
  AGGTCTACAGTATGTAGAAGCAGAAGTTAGTATTAATGAGGATGGTACCTTGTTTGATGG
  TCGACCAATAGAGTCTCTGTCCCTGATAGATGCCGTAATGCCTGATGTAGTACAAACAAG
  ACAACAAGCTTATAGAGATAAGCTTGCACAGCAACAGGCAGCAGCTGCTGCAGCTGCCGC
  AGCTGCAGCCAGCCAACAAGGATCTGCAAAAAATGGAGAAAACACAGCAAATGGGGAGGA
  GAATGGAGCACATACTATAGCAAATAATCATACTGATATGATGGAAGTGGATGGGGATTG
  TTGAAATCCCTCCTAATAAAGCTTGTTGTGTTGCGGCGCCATGAATCTGAAGTTTTTATC
  TGTGCCTGGAACCTTGTTAGTGATCTCCTAGCATTAGGGTCTGGAGACTCAACACCAGAA
  TTTGGAATCTTAGTGAGAACAGCACCAGTGGCTCTACCCAGTTATACTTAAACATTGGAT
  ACAAGAGGAAGGCAAGATGTTCCACCACCAGGATGCCCATCTCTAGATGGAATAGTGAGG
  ACACTTTTACCACTGTTTCTATGAGGGTTGCAAAAAA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_024665 unedited
  GCAATCTAGAGTCGAGTTNTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCCCTTACCC
  AAAAACATTTTAATCTTTTAAAAAACAAAGCAAAACAAACAACCACCAAAAACCCCAAAA
  CTACGTTGCTCCTTTTCACAATAGGGCACATTTTTACCATAATTTAGTTATGGCTACAAA
  ACATCAAAAAATTTTTTTAAGGTATCTTCTCTATGGAAATTAAAAAAAAAGTTGGGCCCT
  TCTAGTCTTTAATTGGCAAAAATATGTCCCAAAAAAAAAACTATTGCATTTAAGCCACTT
  CCCCAAAAACCAAAAAGGAAAAAAAAAAAAAAAAAGGCAAACCAAAAAAACAAACCCAAC
  AGAGCATAATACCCTTTTACTGATGGGTCTTACAGATTGACATGACCAAAGTCATAGGTT
  TTCATTTAATTTCCAATTCCCCCTTCCACAACATGCACCAACTGAATATATGCTCTGGGA
  GCCATAAAATGTACCAAACATCTACCTCTTCAAAAGAATGCATTAAAATATTTTAAAGAA
  TTTTTTGTTTAAAAGGTGAAAAAAATTAACCAAGAAACTGATTCACTCCCTTACTTCATG
  CATCCATAATCTAACCCAAAAACGATATTTTAAAGCAAGACCAAACTACTGCTGCAAGTT
  TTTGTAAGTCCATTTTCTCTGTCATACAAACTGCTCCTACTGAGGGGAAAAAAAGATATA
  TCCATGTGGCTGCTGATTCAAAGGGAGAACAAGCTGTATTTAGTTCCAAAACTGGACAGT
  ATGTTCGGTTTATAAGAAATTTTCCCTCTCGGTTTAAAACCAAACTCTAAGGCTTTTTAG
  GCACAGAGATAAATCCAGCCTTGGGAACGAATTCAAGCTGGACAAATTTGCTCTCAGGGG
  CCATTTGTTTATACACGATTAAATATTTTTAAATGGCTGAGGACCGCCAGTTCCAGGGNA
  TTTCCN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_024665
• Insert Size: 2660 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_024665.3, NP_078941.2
• RefSeq Size: 5911 bp
• RefSeq ORF: 1545 bp
• Locus ID: 79718
• UniProt ID: Q9BZK7
• Cytogenetics: 3q26.32
• Domains: WD40, LisH
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Wnt signaling pathway
• Gene Summary: This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]