hnRNP A2B1 (HNRNPA2B1) (NM_002137) Human Untagged Clone

CAT#: SC109310

HNRNPA2B1 (untagged)-Human heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), transcript variant A2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: hnRNP A2B1
• Synonyms: HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1; IBMPFD2; RNPA2; SNRPB1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_002137, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAGAGAGAAAAGGAACAGTTCCGTAAGCTCTTTATTGGTGGCTTAAGCTTTGAAACCACAGAAGAAA
  GTTTGAGGAACTACTACGAACAATGGGGAAAGCTTACAGACTGTGTGGTAATGAGGGATCCTGCAAGCAA
  AAGATCAAGAGGATTTGGTTTTGTAACTTTTTCATCCATGGCTGAGGTTGATGCTGCCATGGCTGCAAGA
  CCTCATTCAATTGATGGGAGAGTAGTTGAGCCAAAACGTGCTGTAGCAAGAGAGGAATCTGGAAAACCAG
  GGGCTCATGTAACTGTGAAGAAGCTGTTTGTTGGCGGAATTAAAGAAGATACTGAGGAACATCACCTTAG
  AGATTACTTTGAGGAATATGGAAAAATTGATACCATTGAGATAATTACTGATAGGCAGTCTGGAAAGAAA
  AGAGGCTTTGGCTTTGTTACTTTTGATGACCATGATCCTGTGGATAAAATCGTATTGCAGAAATACCATA
  CCATCAATGGTCATAATGCAGAAGTAAGAAAGGCTTTGTCTAGACAAGAAATGCAGGAAGTTCAGAGTTC
  TAGGAGTGGAAGAGGAGGCAACTTTGGCTTTGGGGATTCACGTGGTGGCGGTGGAAATTTCGGACCAGGA
  CCAGGAAGTAACTTTAGAGGAGGATCTGATGGATATGGCAGTGGACGTGGATTTGGGGATGGCTATAATG
  GGTATGGAGGAGGACCTGGAGGTGGCAATTTTGGAGGTAGCCCCGGTTATGGAGGAGGAAGAGGAGGATA
  TGGTGGTGGAGGACCTGGATATGGCAACCAGGGTGGGGGCTACGGAGGTGGTTATGACAACTATGGAGGA
  GGAAATTATGGAAGTGGAAATTACAATGATTTTGGAAATTATAACCAGCAACCTTCTAACTACGGTCCAA
  TGAAGAGTGGAAACTTTGGTGGTAGCAGGAACATGGGGGGACCATATGGTGGAGGAAACTATGGTCCAGG
  AGGCAGTGGAGGAAGTGGGGGTTATGGTGGGAGGAGCCGATACTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002137 unedited
  NGAGGTGATCATAGGNATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGTCCCG
  TGCGGAGGTGTTCCTCGCAGAGTTGTTTCTCGAGCAGCGGCAGTTCTCACTACAGCGCCA
  GGACGAGTCCGGTTCGTGTTCGTCCGCGGAGATCTCTCTCATCTCGCTCGGCTGCGGGAA
  ATCGGGCTGAAGCGACTGAGTCCGCGATGGAGAGAGAAAAGGAACAGTTCCGTAAGCTCT
  TTATTGGTGGCTTAAGCTTTGAAACCACAGAAGAAAGTTTGAGGAACTACTACGAACAAT
  GGGGAAAGCTTACAGACTGTGTGGTAATGAGGGATCCTGCAAGCAAAAGATCAAGAGGAT
  TTGGTTTTGTAACTTTTTCATCCATGGCTGAGGTTGATGCTGCCATGGCTGCAAGACCTC
  ATTCAATTGATGGGAGAGTAGTTGAGCCAAAACGTGCTGTAGCAAGAGAGGAATCTGGAA
  AACCAGGGGCTCATGTAACTGTGAAGAAGCTGTTTGTTGGCGGAATTAAAGAAGATACTG
  AGGAACATCACCTTAGAGATTACTTTGAGGAATATGGAAAAATTGATACCATTGAGATAA
  TTACTGATAGGCAGTCTGGAAAGAAAAGAGGCTTTGGCTTTGTTACTTTTGATGACCATG
  ATCCTGTGGATAAAATCGTATTGCAGAAATACCATACCATCAATGGTCATAATGCAGAAG
  TAAGAAAGGCTTTGTCTAGACAAGAATGCANGAAGTTCAGAGTTCTAGGAGTGGAAGAGG
  AGGCAACTNTGGCTTTGGGGATTCACGTGGTGGCGGTGGAAATTTTCGACCCAGACCAGG
  AATAACTTTAAAGGGAGATCTGATGGATATGCCATTGGACCTGGACTTTGGGATGGCTTT
  ATCGCTATG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002137 unedited
  TTGTACGCGGCCGCAATCTANAACCGAGTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTTCCTTGAAAATTATTTTATTAAATCATAAGGGCCCAACCGCTTTTTA
  ACTTTCCACCCCCCCTTAAATTTTTTTAAGGGAAAAACGTTTTGTTTTATTACACCGTGA
  CCCTGGTTAAAAGCTTTTAAAAACTTTGAAAAAAAATCTTAAAAAAGGTTTACACATGTC
  ACCTGAAACTTACAAATTTAACTTTATCAAAAAAGGAAGGTTTTTACATTTTTACAAAAA
  CCCCTTAAAAGAAACACCATTCAAAAAGCTAAAAACCTGTCTAAAAGGCTTTTTTTTTTA
  CAATCTTTCCTCCAAAGTAGGGGAAGGTTATTAAATAATCCACCCCATTCACAAAAGGGC
  CCTCTGAATTGGCCCTGGGGTTTTCTGCCATATCACTGCATATTTATGCATGATTGAAAT
  AAAAGCTTCTTTACCATTGCCATTCCAACAACCTGAACCTGCCTTGTCCCCTTGGGGCTC
  TCATCCCTCCCTATTATACAGGGACCCCCTTGGCAACACGGAAAAACCCACACTCGGGCT
  CCCCCCACCATAACCGCCTTTAGCTACCTGGACCCGGGACCATACCCCCCTCATTATATG
  GCTTCCCCCCTCCTTCGCCCCTCTATATTTTCACTCTACCCCCCCCCCCATGCGCCAACG
  GTGCCGCTCACCCCTCCAACACCTTGGCGCTCTTCACCCCCCAATATTTTTCCCACATCC
  CGCCTTCCCCCACTTTCCCCCCCCCCTCTGGTTCCCCCCCCTCCCTTTCTTTTCCCCCTT
  TCCCCCCCCTCCCCCCTTTTTTGTTCTTTCCCCTCCCCCCGCACCATCCTCCTATTTTAT
  TCCTGTTTCCCCTCCCATCTCCCCCCCCACCTCCCTTTCCCACCCCTCTTCTCCCCCCAC
  TT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002137
• Insert Size: 1770 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002137.2, NP_002128.1
• RefSeq Size: 1714 bp
• RefSeq ORF: 1026 bp
• Locus ID: 3181
• UniProt ID: P22626
• Cytogenetics: 7p15.2
• Domains: RRM
• Protein Families: Druggable Genome
• Gene Summary: This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (A2) lacks 36 bases at the beginning of the coding region compared to variant B1. The N-terminus of isoform A2 is thus different from isoform B1. This isoform (A2) is the predominant protein.