ADCY4 (NM_139247) Human Untagged Clone

SKU SC100206

ADCY4 (untagged)-Human adenylate cyclase 4 (ADCY4), transcript variant 2

Product Data

• Type: Human Untagged Clone
• Target Symbol: ADCY4
• Synonyms: AC4
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_139247 edited; GCCCTTGCGGGTGAGAAAAGCTCAGGTGGGGCCCGCCGGGCCGAAGGAGGTAACCCGGCG; CCCGGCCCTAGCCAGCCCCGGGGCTCGGGGCTGGGGAGATCATGGCCCGCCTCTTCAGCC; CCCGGCCGCCCCCCAGCGAAGACCTCTTCTACGAGACCTACTACAGCCTGAGCCAGCAGT; ACCCGCTGCTGCTGCTGCTGCTGGGGATCGTGCTCTGTGCGCTCGCGGCGCTGCTCGCAG; TGGCCTGGGCCAGCGGCAGGGAGCTGACCTCAGACCCGAGCTTCCTGACCACTGTGCTGT; GCGCGCTGGGCGGCTTCTCGCTGCTGCTGGGCCTCGCTTCCCGGGAGCAGCGACTGCAGC; GCTGGACGCGTCCCCTGTCCGGCTTGGTATGGGTCGCGCTGCTAGCGCTAGGCCACGCCT; TCCTGTTCACCGGGGGCGTGGTGAGCGCCTGGGACCAGGTGTCCTATTTTCTCTTCGTCA; TCTTCACGGCGTATGCCATGCTGCCCTTGGGCATGCGGGACGCCGCCGTCGCGGGCCTCG; CCTCCTCACTCTCGCATCTGCTGGTCCTCGGGCTGTATCTTGGGCCACAGCCGGACTCAC; GGCCTGCACTGCTGCCGCAGTTGGCAGCAAACGCAGTGCTGTTCCTGTGCGGGAACGTGG; CAGGAGTGTACCACAAGGCGCTGATGGAGCGCGCCCTGCGGGCCACGTTCCGGGAGGCAC; TCAGCTCCCTGCACTCACGCCGGCGGCTGGACACCGAGAAGAAGCACCAGGAACACCTTC; TCTTGTCCATCCTTCCTGCCTACCTGGCCCGAGAGATGAAGGCAGAGATCATGGCACGGC; TGCAGGCAGGACAGGGGTCACGGCCAGAGAGCACTAACAATTTCCACAGCCTCTATGTCA; AGAGGCACCAGGGAGTCAGCGTGCTGTATGCTGACATCGTGGGCTTCACGCGGCTGGCCA; GCGAGTGTTCCCCTAAGGAGCTGGTGCTCATGCTCAATGAGCTCTTTGGCAAGTTCGACC; AGATTGCCAAGGAGCATGAATGCATGCGGATCAAGATCCTGGGGGACTGTTACTACTGTG; TCTCTGGGCTGCCACTCTCACTGCCAGACCATGCCATCAACTGCGTGCGCATGGGCCTGG; ACATGTGCCGGGCCATCAGGAAACTGCGGGCAGCCACTGGCGTGGACATCAACATGCGTG; TGGGCGTGCACTCAGGCAGCGTACTGTGTGGAGTCATCGGGCTGCAGAAGTGGCAGTACG; ACGTTTGGTCACATGATGTCACACTGGCTAACCACATGGAGGCAGGCGGTGTACCAGGGC; GAGTGCACATCACAGGGGCTACCCTGGCCCTGCTGGCAGGGGCTTATGCTGTGGAGGACG; CAGGCATGGAGCATCGGGACCCCTACCTTCGGGAGCTAGGGGAGCCTACCTATCTGGTCA; TCGATCCACGGGCAGAGGAGGAGGATGAGAAGGGCACTGCAGGAGGCTTGCTGTCCTCGC; TTGAGGGCCTCAAGATGCGTCCATCACTGCTGATGACCCGTTACCTGGAGTCCTGGGGCG; CAGCCAAGCCTTTTGCCCACCTGAGCCACGGAGACAGCCCTGTGTCCACCTCCACCCCTC; TCCCGGAGAAGACCCTGGCTTCCTTCAGCACCCAGTGGAGCCTGGATCGGAGCCGTACCC; CCCGGGGACTAGATGATGAACTGGACACCGGGGATGCCAAGTTCTTCCAGGTCATTGAGC; AGCTCAACTCGCAGAAACAGTGGAAGCAGTCGAAGGACTTCAACCCACTGACACTGTACT; TCAGAGAGAAGGAGATGGAGAAAGAGTACCGACTCTCTGCAATCCCCGCCTTCAAATACT; ATGAAGCCTGCACCTTCCTGGTTTTTCTCTCCAACTTCATCATCCAGATGCTAGTGACAA; ACAGGCCCCCAGCTCTGGCCATCACGTATAGCATCACCTTCCTCCTCTTCCTCCTCATCC; TTTTTGTCTGCTTCTCAGAGGACCTGATGAGGTGTGTCCTGAAAGGCCCCAAGATGCTGC; ACTGGCTGCCTGCACTGTCTGGCCTGGTGGCCACACGACCAGGACTGAGAATAGCCTTGG; GCACCGCCACCATCCTCCTTGTCTTTGCCATGGCCATTACCAGCCTGTTCTTCTTCCCAA; CATCATCAGACTGCCCTTTCCAAGCTCCCAATGTGTCCTCCATGATTTCCAACCTCTCCT; GGGAGCTCCCTGGGTCTCTGCCTCTCATCAGTGTCCCATACTCCATGCACTGCTGCACGC; TGGGCTTCCTCTCCTGCTCCCTCTTTCTGCACATGAGCTTCGAGCTGAAGCTGCTGCTGC; TCCTGCTGTGGCTGGCGGCATCCTGCTCCCTCTTCCTGCACTCCCATGCCTGGCTGTCGG; AATGCCTCATCGTCCGCCTCTATCTGGGCCCCTTGGACTCCAGGCCCGGAGTGCTGAAGG; AGCCCAAACTGATGGGTGCTATCTCCTTCTTCATCTTCTTCTTCACCCTCCTTGTCCTGG; CTCGCCAGAATGAGTACTACTGCCGCCTGGACTTCCTGTGGAAGAAGAAGCTGAGGCAGG; AGAGGGAGGAGACAGAGACGATGGAGAACCTGACTCGGCTGCTCTTGGAGAACGTGCTCC; CTGCACACGTGGCCCCCCAGTTCATTGGCCAGAACCGGCGCAACGAGGATCTCTACCACC; AGTCCTATGAATGCGTTTGTGTCCTCTTCGCCTCAGTCCCAGACTTCAAGGAGTTCTACT; CTGAATCCAACATCAATCATGAGGGCCTAGAGTGTCTGAGGCTGCTCAATGAGATAATTG; CTGATTTTGATGAGCTGCTCTCCAAGCCCAAGTTCAGTGGGGTGGAGAAGATCAAGACCA; TCGGCAGCACCTACATGGCAGCCACAGGCTTAAATGCCACCTCTGGACAGGATGCACAAC; AGGATGCTGAACGGAGCTGCAGCCACCTTGGCACTATGGTGGAATTTGCCGTGGCCCTGG; GGTCTAAGCTGGACGTCATCAACAAGCATTCATTCAACAACTTCCGCCTGCGAGTGGGGT; TGAACCATGGACCCGTAGTAGCTGGAGTTATTGGGGCCCAGAAGCCGCAATATGACATTT; GGGGCAACACAGTGAACGTGGCCAGCCGCATGGAGAGTACAGGAGTCCTTGGCAAAATCC; AAGTGACTGAGGAGACAGCATGGGCCCTACAGTCCCTGGGCTACACCTGCTACAGCCGGG; GTGTCATCAAGGTGAAAGGCAAAGGGCAGCTCTGCACCTACTTCCTGAACACAGACTTGA; CACGAACTGGACCTCCTTCAGCTACCCTAGGCTGAGATTGCACTCGCCTTCTAAGAACC;
• Restriction Sites: Please inquire
• ACCN: NM_139247
• Insert Size: 3360 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_139247.2.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_139247.2, NP_640340.2
• RefSeq Size: 3320 bp
• RefSeq ORF: 3234 bp
• Locus ID: 196883
• UniProt ID: Q8NFM4
• Cytogenetics: 14q12
• Domains: CYCc
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Calcium signaling pathway, Chemokine signaling pathway, Dilated cardiomyopathy, Gap junction, GnRH signaling pathway, Melanogenesis, Oocyte meiosis, Progesterone-mediated oocyte maturation, Purine metabolism, Taste transduction, Vascular smooth muscle contraction
• Summary: This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]; Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.