BCL10 (NM_003921) Human Tagged ORF Clone
CAT#: RC208752
BCL10 (Myc-DDK-tagged)-Human B-cell CLL/lymphoma 10 (BCL10)
Specifications
Product Data | |
Product Name | BCL10 (NM_003921) Human Tagged ORF Clone |
Symbol | BCL10 |
Synonyms | c-E10; CARMEN; CIPER; CLAP; IMD37; mE10 |
Vector | pCMV6-Entry |
Sequence Data |
>RC208752 representing NM_003921
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGCCCACCGCACCGTCCCTCACCGAGGAGGACCTCACTGAAGTGAAGAAGGACGCCTTAGAAAATT TACGTGTATACCTGTGTGAGAAAATCATAGCTGAGAGACATTTTGATCATCTACGTGCAAAAAAAATACT CAGTAGAGAAGACACTGAAGAAATTTCTTGTCGAACATCAAGTAGAAAAAGGGCTGGAAAATTGTTAGAC TACTTACAGGAAAACCCAAAAGGTCTGGACACCCTTGTTGAATCTATTCGGCGAGAAAAAACACAGAACT TCCTGATACAGAAGATTACAGATGAAGTGCTGAAACTTAGAAATATAAAACTAGAACATCTGAAAGGACT AAAATGTAGCAGTTGTGAACCTTTTCCAGATGGAGCCACGAACAACCTCTCCAGATCAAATTCAGATGAG AGTAATTTCTCTGAAAAACTGAGGGCATCCACTGTCATGTACCATCCAGAAGGAGAATCCAGCACGACGC CCTTTTTTTCTACTAATTCTTCTCTGAATTTGCCTGTTCTAGAAGTAGGCAGAACTGAAAATACCATCTT CTCTTCAACTACACTTCCCAGACCTGGGGACCCAGGGGCTCCTCCTTTGCCACCAGATCTACAGTTAGAA GAAGAAGGAACTTGTGCAAACTCTAGTGAGATGTTTCTTCCCTTAAGATCACGTACTGTTTCACGACAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC208752 representing NM_003921
Red=Cloning site Green=Tags(s) MEPTAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLD YLQENPKGLDTLVESIRREKTQNFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFPDGATNNLSRSNSDE SNFSEKLRASTVMYHPEGESSTTPFFSTNSSLNLPVLEVGRTENTIFSSTTLPRPGDPGAPPLPPDLQLE EEGTCANSSEMFLPLRSRTVSRQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Chromatograms |
CHROMATOGRAMS
![]() Sequencher program is needed, download here. |
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
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Tag | Myc-DDK |
ACCN | NM_003921 |
ORF Size | 699 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers. |
Reference Data | |
RefSeq | NM_003921.1, NM_003921.2, NM_003921.3, NM_003921.4, NP_003912 |
RefSeq Size | 3271 |
RefSeq ORF | 702 |
Locus ID | 8915 |
Cytogenetics | 1p22.3 |
Domains | CARD |
Protein Families | Druggable Genome |
Protein Pathways | T cell receptor signaling pathway, B cell receptor signaling pathway |
MW | 26.1 kDa |
Gene Summary | This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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Impaired RASGRF1/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians
,Gavino, C;Hamel, N;Zeng, JB;Legault, C;Guiot, MC;Chankowsky, J;Lejtenyi, D;Lemire, M;Alarie, I;Dufresne, S;Boursiquot, JN;McIntosh, F;Langelier, M;Behr, MA;Sheppard, DC;Foulkes, WD;Vinh, DC;,
J. Allergy Clin. Immunol. Oct 2015
,PubMed ID 26521038
[BCL10]
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Documents
Product Manuals |
FAQs |
SDS |
Resources
cDNA Clone Resources |
Other Versions
SKU | Description | Size | Price |
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RC208752L4V | Lenti ORF particles, BCL10 (mGFP-tagged) - Human B-cell CLL/lymphoma 10 (BCL10), 200ul, >10^7 TU/mL |
USD 930.00 |
|
RC208752L1 | Lenti ORF clone of Human B-cell CLL/lymphoma 10 (BCL10) , Myc-DDK-tagged |
USD 620.00 |
|
RC208752L4 | Lenti ORF clone of Human B-cell CLL/lymphoma 10 (BCL10), mGFP tagged |
USD 680.00 |
|
RC208752L1V | Lenti ORF particles, BCL10 (Myc-DDK tagged) - Human B-cell CLL/lymphoma 10 (BCL10) , 200ul, >10^7 TU/mL |
USD 830.00 |
|
RG208752 | BCL10 (GFP-tagged) - Human B-cell CLL/lymphoma 10 (BCL10) |
USD 460.00 |
|
SC117685 | BCL10 (untagged)-Human B-cell CLL/lymphoma 10 (BCL10) |
USD 300.00 |
|
RC208752L3V | Lenti ORF particles, BCL10 (Myc-DDK tagged) - Human B-cell CLL/lymphoma 10 (BCL10) , 200ul, >10^7 TU/mL |
USD 830.00 |
|
RC208752L2V | Lenti ORF particles, BCL10 (mGFP-tagged) - Human B-cell CLL/lymphoma 10 (BCL10), 200ul, >10^7 TU/mL |
USD 930.00 |
|
RC208752L2 | Lenti ORF clone of Human B-cell CLL/lymphoma 10 (BCL10), mGFP tagged |
USD 680.00 |
|
RC208752L3 | Lenti ORF clone of Human B-cell CLL/lymphoma 10 (BCL10) , Myc-DDK-tagged |
USD 620.00 |
USD 299.00
USD 550.00