Topors (NM_134097) Mouse Untagged Clone

CAT#: MC223289

Topors (untagged) - Mouse topoisomerase I binding, arginine/serine-rich (Topors), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Topors
• Synonyms: AW105885; LUN; p53BP3/LUN; TP53BPL
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC223289 representing NM_134097
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGGGTCGCAGCCGCCGCCACCGGGGTCTCCGCTGTCTCGCGAGGAGGGTGAAGCGCCCCCTCTGGTGC
  CTGCCGAGGAGGGGAGGCGCCGAAGCCGCCGGGTACGCCTTCGCGGATCCTGCCGCCACCGGCCGAGCTT
  ACTGAGCCGGCGGGAGCTGGCTTCCAACGGCCCAGCGGTTCCTGCCACCGCGTCCTCGGAGATAATGGCC
  TCAGCTGCTAAGGAATTTAAAATGGACAACTTTTCACCTAAAGCTGGCACTAGCAAATTGCAGCAGACAG
  TACCAGCTGATGCGTCTCCTGATTCTAAGTGTCCTATATGCTTGGATAGATTTGATAATGTGTCTTACTT
  AGATCGTTGCCTACATAAGTTCTGTTTTCGCTGTGTACAAGAGTGGTCCAAAAACAAAGCCGAATGCCCA
  CTGTGTAAACAGCCCTTTGATTCTATTTTCCATTCAGTGAGGGCTGAAGATGACTTCAAGGAGTATGTCC
  TGAGGCCTTCCTATAATGGTTCCTTTACTAACCCTGAGGTTCGAAGGTTTCGCTACCGGACAACTATGAC
  GAGAGAACGGAGCGCCTCTCTTTATTCACCCAGTAGTACTGTAAGTAGGAGAACAACCACGCCACCAGAT
  AGTGGAGTGCTGTTTGAAGGGTTAGGCATTTCGACAAGACCTAGAGATGTTGACATTCCTCAATTTATGA
  GACAAATGGCATTAAGGGGGCCAACTACTACAGATGAGAGATCTTTGCGGAAAATTCAAGAACAAGATAT
  TATTAATTTCAGGCGAACTCTTTATCGTGCTGGTGTTCGAGTTAGAAGTATTGAAGATGGTGGCCGCTAC
  AGGGATATTTCAGCTGAGTTCTTCCGTAGAAATCCAGCTTGCCTTCACAGATTAGTTCCTTGGTTAAAGC
  GTGAACTTACTGTGCTTTTTGGAGCCCATGGTTCGCTAGTCAATATCGTCCAGCACATCATCATGAGTAA
  TGTTACTCGCTATGATTTGGAGAGTCAGGCATTTGTGTCTGACTTAAGACCATTTTTGCTTAATCGAACT
  GAGCATTTTATACATGAATTTATCAGTTTTGCTAGATCTCCCTTCAATATGGCAGCTTTTGACCAGCATG
  CTAATTATGATTGCCCTCCTTCATCTGAAGAAGGCAGCCGTTCAGATTCTTCAGTCATTACAATATCACC
  AGATGAGGCTGAAACTCAAGAGCTAGATATGAATGCATCTACTGTTAGGCAGGCACCGTGGGATGATGAA
  ACTCCTGGACCATCTTATTCAAGTTCAGAGCAAGTGCATGTTGGCGTGTCTTCCCTTTTAAATTCTTCAG
  ACAGTTCAGATGAAGAGCTTGTCTCTGGAGGAACCACATCTCAGATACAAGGAGTACAGACCAATGACGA
  TGTCAATAATGACAGTGATTCATCGTCAGATAATTGTGTCATTGTTGGGTTTGTTAAGCCATTGGCTGAA
  AGGACCCCGGAACTTGTTGAACTGTCTTCTGATTCTGAGGAGTTGGGCCCTTATGAGAAAGTGGAGACAG
  TGAAGACTCAGGAGCAAGAGCAGTCGTACAGTTCAGGTGACAGTGATGTTAGCCGGGCGTCATCTCCACG
  CTCTGTCCTTGGAAAAGATGAACAAATGAGTAAAAGCCATTGTGATTCTGACACAAGAATAAGCTCAAAG
  AAAGAAGAGAAACGATCTACATCATTGCCAGCTCCCAGGGACAGCTCATCTACAAGAGGTGACAGGGTAT
  GCTCCCCATATAACCATCGACACAGGAAGGGAGGAAGGTCGAGGAGTTCAGATTCCCGGTCCCAGAGTAG
  AAGTGGCCATGACCCGAGGAATCACAGGAAGCACGGGAAGAAAAGACTGAGGAACAAGAGGTCCAGAAGC
  AGGGAGAGTAGTAGCAGGCCGAGAGCAAGAAAGGACAAAAAGAGATCCAGAACTAGAGATAGCAGCTGGT
  CCCGGAGGAGCCAGACACTTTCTCTAAGTAGTGGAAGCACCAGTAGATCGAGGTCTCGTAGCAGTGATCA
  TGGCAAAAGAAGATCACGAAGCAGAAATCGAGATCGCTATTATTTAAGAAATAATTATGGAAGCAAATAT
  AAGTGGGAATACACTTACTACAGCAGAAACAAGGACAGAGATGGCTATGAATCATCATACAGGAGGAGGA
  CTCTTTCAAGAGCCCATTACTCTAGACAGTCTTCAAGTCCAGAATTTAGAATTCAGTCTTTTTCTGAAAG
  AACAAATGCGAGGAAGAAGAATCACAGTGAAAGGAAATACTACTACTATGAAAGGCGCCGGTCCAGGAGC
  GTGTCCAGTAACAGGTCGAGGACTACATCCGCCGGGCCCGACCGGGTGAGAAATGAGAAGCCCGGAGGGA
  AACGCAAGTACAAAACCCGGCATTTGGAAGGTACCAGTGAAGAGGCTCAGCCGGCTCGGGAGTTCACTTC
  CAAAGGGAAGGACAGTCATTACCAAAAATCAAAATTGGATGGCAGTTATAAAAATGAGAGTGACAGCTTT
  TCAGATAGCAGATCATCAGACAGAGAGACAAAACACAAGAGGAGGAGGAGGAGGACCCGGAGCCTAAGTG
  TAGAGATAGTTTATGAAGGAAAGGCTACGGACACAAGCAAACACCATAAGAAGAAAAAGAAGAAACATAA
  GAAGAAGCATAAGAAACACCATGGAGATAATACTTCACGGTCGCCGGTGGTTATAACCATCGACAGTGAC
  AGCGATGGAGAGTCTGAAGTAAAGGCGGGTATTGAATGTAGCAATGGCAGTCTTCCACAGCCTATACAAG
  ATGGAGCATTTGAAACTAAAGATGTTGTCACAATCGAAGATGAGCTTGGTGTCCTGGACAAGGACTGTGA
  CGTTACAGCACTTGCTGATGACTTGAGCACCAGCCAAACTGTGGAGAATTGTGACTCGCCGGCAGTCCCA
  GTTGAACAAACTCTTGATGTAAGAGAAGAAAGCACCTTTGCCTCTGATTTGGAGAGCCAGTCGAGTAATG
  TGTCTATTCAGGCTGAACCATCGAGACCAGTGCCATCTCCACGGACCTCACTGTCATCAGTGTCTCCTGG
  TAGAGACTGTGATGTGTCTTAA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_134097
• Insert Size: 3102 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_134097.3, NP_598858.2
• RefSeq Size: 3842 bp
• RefSeq ORF: 3102 bp
• Locus ID: 106021
• UniProt ID: Q80Z37
• Cytogenetics: 4 A5
• Gene Summary: Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation.[UniProtKB/Swiss-Prot Function]