Human REG1 alpha (REG1A) ELISA KIT (1 x 96 wells)
$495.00
2 Weeks*
| Product Data | |
| Species | Human |
|---|---|
| Format | 8x12 divisible strips |
| Assay Type | Sandwich |
| Assay Length | 3.5 hours incubations; 1 hour washing and analyzing samples |
| Signal | Colorimetric |
| Curve Range | 15.6pg/ml-1000pg/ml |
| Sample Type | Human serum, plasma and other biological fluids. |
| Sample Volume | 100µl |
| Specificity | This kit is used for quantitative detection of Human PSP/REG1A |
| Sensitivity | 5.3pg/ml |
| Reactivity | Human |
| Cross Reactivity | There is no detectable cross-reactivity with other relevant proteins. |
| Interference | No significant interference observed with available related molecules. |
| Components |
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| Background | Pancreatic stone protein (PSP), also known as lithostathine, and regenerating protein (REG1A). It is a secreted, type I subclass member of the regenerating protein family. Mature human PSP/REG1A shares 76% and 69% aa sequence identity with mouse and rat PSP/REG1A, respectively. PSP/REG1A is constitutively expressed by pancreatic acinar cells, and is also induced in proliferating cell types such as colonic epithelium, islet beta-cells, and multiple tumor types. The 16 kDa precursor of PSP/REG1A has been observed mainly in the pancreas and is transiently elevated in acute and chronic pancreatitis. PSP/REG1A has been found both in blood and pancreatic secretions. PSP/REG1A plays a role in blocking apoptosis, and is upregulated by both IL-22 and IL-6. Under healthy conditions PSP/REG1A is expressed at low levels in the pancreas. Upon focal or systemic inflammation, PSP/REG1A is strongly increased. PSP/REG1A is elevated in various conditions such as sepsis, ventilator associated pneumonia (VAP), chronic obstructive pulmonary disease (COPD) exacerbation, and type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). These observations indicated that PSP/REG1A might respond to infectious conditions and organ failure. The use of the PSP/REG1A as a biomarker has been confirmed the high diagnostic accuracy for sepsis. In addition, evidences obtained regarding PSP/REG1A and its isoforms on regeneration, growth and mitogenesis in gastrointestinal neoplastic diseases suggest that PSP/REG1A can be used as biomarker in the prediction of prognosis for neoplastic diseases. |
| Gene Symbol | REG1A |
| Locus ID | 5967 |
| Standard Curve |
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| Shipping | Blue Ice |
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| Datasheet | |
| SDS | |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.