Human REG1 alpha (REG1A) ELISA KIT (1 x 96 wells)
Human PSP/REG1A ELISA Kit for the detection of Human PSP/REG1A in serum, plasma and other biological fluids.
|Format||8x12 divisible strips|
|Assay Type||Sandwich ELISA kit of Quantitative Detection for Human PSP/REG1A|
|Assay Length||3.5 hours incubations; 1 hour washing and analyzing samples|
|Sample Type||Human serum, plasma and other biological fluids.|
|Specificity||This kit is used for quantitative detection of Human PSP/REG1A|
|Cross Reactivity||There is no detectable cross-reactivity with other relevant proteins.|
|Interference||No significant interference observed with available related molecules.|
|Background||Pancreatic stone protein (PSP), also known as lithostathine, and regenerating protein (REG1A). It is a secreted, type I subclass member of the regenerating protein family. Mature human PSP/REG1A shares 76% and 69% aa sequence identity with mouse and rat PSP/REG1A, respectively. PSP/REG1A is constitutively expressed by pancreatic acinar cells, and is also induced in proliferating cell types such as colonic epithelium, islet beta-cells, and multiple tumor types. The 16 kDa precursor of PSP/REG1A has been observed mainly in the pancreas and is transiently elevated in acute and chronic pancreatitis. PSP/REG1A has been found both in blood and pancreatic secretions. PSP/REG1A plays a role in blocking apoptosis, and is upregulated by both IL-22 and IL-6. Under healthy conditions PSP/REG1A is expressed at low levels in the pancreas. Upon focal or systemic inflammation, PSP/REG1A is strongly increased. PSP/REG1A is elevated in various conditions such as sepsis, ventilator associated pneumonia (VAP), chronic obstructive pulmonary disease (COPD) exacerbation, and type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). These observations indicated that PSP/REG1A might respond to infectious conditions and organ failure. The use of the PSP/REG1A as a biomarker has been confirmed the high diagnostic accuracy for sepsis. In addition, evidences obtained regarding PSP/REG1A and its isoforms on regeneration, growth and mitogenesis in gastrointestinal neoplastic diseases suggest that PSP/REG1A can be used as biomarker in the prediction of prognosis for neoplastic diseases.|
Data image for REG1 alpha (REG1A) ELISA Kit.
|Assay Kit Resources|