Rat IL-2 ELISA Kit (48-well)
| Product Data | |
| Species | Rat |
|---|---|
| Format | 48-well strip plate |
| Assay Type | Solid Phase Sandwich ELISA |
| Assay Length | 3 hour |
| Signal | Colorimetric |
| Curve Range | 0.03 - 2.0 ng/mL |
| Sample Type | Cell culture supernatant, serum, plasma (EDTA, citrate, heparin) |
| Sample Volume | 20 uL |
| Specificity | Natural and recombinant Rat IL-2 Ligand |
| Sensitivity | 7pg/mL |
| Reactivity | Rat |
| Interference | No significant interference observed with available related molecules. |
| Components |
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| Background | Interleukin 2 (IL-2) is a pleiotropic cytokine produced primarily by mitogen- or antigen-activated T lymphocytes . It plays a key role in promoting the clonal expansion of antigen-specific T cells. In addition, IL-2 has been shown to mediate multiple immune responses on a variety of cell types. IL-2 has been found to stimulate growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendocytes. IL-2 is involved in treatment of cancers such as melanoma and renal cell cancer. It plays a key role in promoting the clonal expansion of antigen-specific T cells. In addition, IL-2 has also been shown to mediate multiple immune responses on a variety of cell types. The sequence of rat IL-2 cDNA predicts a 155 amino acid (aa) residue precursor glycoprotein containing a 20 aa residue signal peptide that is cleaved to form the mature protein . At the amino acid sequence level, mature rat IL-2 is approximately 80% identical to mouse IL-2 . The biological effects of IL-2 are mediated by specific cell surface receptor complexes. The functional high-affinity receptor for IL-2 is composed of three distinct polypeptide chains. IL-2 stimulates the proliferation of thymocytes; stimulates the proliferation and differentiation of activated B cells; promotes the growth, differentiation and cytocidal activity of monocytes; induces the growth of and cytokine production and cytolytic activity by natural killer cells; enhances the production of lymphocyte-activated killer (LAK) cells; and induces the proliferation and differentiation of oligodendrocytes . |
| Gene Symbol | Il2 |
| Locus ID | 116562 |
| Standard Curve |
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| Shipping | Blue Ice |
| Datasheet | |
| SDS | |