EWSR1 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3F6]

CAT#: TA813056AM

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EWSR1 mouse monoclonal antibody,clone OTI3F6, Biotinylated



  View other "OTI3F6" antibodies (4)

USD 462.00


Availability*
2 Weeks

Size
    • 100 ul


Specifications

Product Data
Clone Name OTI3F6
Applications IF, IHC, WB
Recommended Dilution WB 1:500, IHC 1:500, IF 1:100
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 256-447 of human EWSR1 (NP_005234) produced in E.coli.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Biotin
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 68.3 kDa
Gene Name EWS RNA binding protein 1
Background This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
Synonyms bK984G1.4; EWS; EWS-FLI1
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency, Transcription Factors

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