MECP2 Mouse Monoclonal Antibody [Clone ID: OTI2F1]
USD 436.00
USD 200.00
Specifications
Product Data | |
Clone Name | OTI2F1 |
Applications | IHC, WB |
Recommended Dilution | WB 1:2000, IHC 1:150 |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 224-486 of human MECP2 (NP_004983) produced in E.coli. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 52.3 kDa |
Gene Name | methyl-CpG binding protein 2 |
Database Link | |
Background | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015] |
Synonyms | AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT |
Reference Data | |
Protein Families | Druggable Genome |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF812397 | Carrier-free (BSA/glycerol-free) MECP2 mouse monoclonal antibody,clone OTI2F1 |
USD 564.00 |
|
TA812397AM | MECP2 mouse monoclonal antibody,clone OTI2F1, Biotinylated |
USD 509.00 |
|
TA812397BM | MECP2 mouse monoclonal antibody,clone OTI2F1, HRP conjugated |
USD 509.00 |
|
TA812397S | MECP2 mouse monoclonal antibody,clone OTI2F1 |
USD 200.00 |
{0} Product Review(s)
Be the first one to submit a review