Serotonin N acetyltransferase (AANAT) Mouse Monoclonal Antibody [Clone ID: OTI3B9]

SKU TA810171

AANAT mouse monoclonal antibody,clone OTI3B9

Product Data

• Clone Name: OTI3B9
• Application: WB
• Recommended Dilution: WB 1:2000
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human recombinant protein fragment corresponding to amino acids 1-72 of human AANAT (NP_001079) produced in E.coli.
• Buffer: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 23.2 kDa
• Gene Name: aralkylamine N-acetyltransferase
• Database Link:
  NP_001079
  Q16613
• Background: The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
• Synonyms: DSPS; SNAT

Reference Data

• Protein Pathways: Metabolic pathways, Tryptophan metabolism